Literature DB >> 20921484

Designing comparative effectiveness research on prescription drugs: lessons from the clinical trial literature.

Dave A Chokshi1, Jerry Avorn, Aaron S Kesselheim.   

Abstract

As comparative effectiveness research becomes a more prominent feature of clinical medicine, investigators and policy makers would do well to seek lessons from prior examples of this type of research. Our analysis of previous examples reveals lessons in three key areas: choice of comparison treatments, time frame of study, and widespread applicability of study results. Based on our observations, we offer suggestions for increasing the clinical applicability of comparative effectiveness research, such as employing surrogate endpoints that meet a specific threshold of validity. Future trials that address these areas of concern hold the greatest promise for improving patients' outcomes.

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Year:  2010        PMID： 20921484     DOI： 10.1377/hlthaff.2010.0843

Source DB:  PubMed          Journal:  Health Aff (Millwood)        ISSN： 0278-2715            Impact factor:   6.301


  8 in total

1.  Radical cystectomy versus bladder-preserving therapy for muscle-invasive urothelial carcinoma: examining confounding and misclassification biasin cancer observational comparative effectiveness research.

Authors:  Justin E Bekelman; Elizabeth A Handorf; Thomas Guzzo; Craig Evan Pollack; John Christodouleas; Matthew J Resnick; Samuel Swisher-McClure; David Vaughn; Thomas Ten Have; Daniel Polsky; Nandita Mitra
Journal:  Value Health       Date:  2013-04-24       Impact factor: 5.725

2.  Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients.

Authors:  Florence T Bourgeois; Karen L Olson; Annapurna Poduri; Kenneth D Mandl
Journal:  Paediatr Drugs       Date:  2015-10       Impact factor: 3.022

3.  Review of quality assessment tools for the evaluation of pharmacoepidemiological safety studies.

Authors:  George A Neyarapally; Tarek A Hammad; Simone P Pinheiro; Solomon Iyasu
Journal:  BMJ Open       Date:  2012-09-25       Impact factor: 2.692

4.  PAYER PERSPECTIVES ON FUTURE ACCEPTABILITY OF COMPARATIVE EFFECTIVENESS AND RELATIVE EFFECTIVENESS RESEARCH.

Authors:  Rachael Moloney; Penny Mohr; Emma Hawe; Koonal Shah; Martina Garau; Adrian Towse
Journal:  Int J Technol Assess Health Care       Date:  2015-01       Impact factor: 2.188

5.  Re-Punching Tissue Microarrays Is Possible: Why Can This Be Useful and How to Do It.

Authors:  Aurélien Lacombe; Vincenza Carafa; Sandra Schneider; Melanie Sticker-Jantscheff; Luigi Tornillo; Serenella Eppenberger-Castori
Journal:  Microarrays (Basel)       Date:  2015-05-11

6.  Comparative effectiveness and safety of oral anticoagulants for atrial fibrillation in real-world practice: a population-based cohort study protocol.

Authors:  Anne Holbrook; Colin Dormuth; Richard Morrow; Agnes Lee; Sue Troyan; Guowei Li; Eleanor Pullenyegum
Journal:  BMJ Open       Date:  2016-11-24       Impact factor: 2.692

7.  IMPACT--Integrative Medicine PrimAry Care Trial: protocol for a comparative effectiveness study of the clinical and cost outcomes of an integrative primary care clinic model.

Authors:  Patricia M Herman; Sally E Dodds; Melanie D Logue; Ivo Abraham; Rick A Rehfeld; Amy J Grizzle; Terry F Urbine; Randy Horwitz; Robert L Crocker; Victoria H Maizes
Journal:  BMC Complement Altern Med       Date:  2014-04-07       Impact factor: 3.659

Review 8.  Growing literature, stagnant science? Systematic review, meta-regression and cumulative analysis of audit and feedback interventions in health care.

Authors:  Noah M Ivers; Jeremy M Grimshaw; Gro Jamtvedt; Signe Flottorp; Mary Ann O'Brien; Simon D French; Jane Young; Jan Odgaard-Jensen
Journal:  J Gen Intern Med       Date:  2014-11       Impact factor: 5.128
  8 in total

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