CONTEXT: Evidence-based treatment trials for adolescents with anorexia nervosa are few. OBJECTIVE: To evaluate the relative efficacy of family-based treatment (FBT) and adolescent-focused individual therapy (AFT) for adolescents with anorexia nervosa in full remission. DESIGN: Randomized controlled trial. SETTING:Stanford University and The University of Chicago (April 2005 until March 2009). PARTICIPANTS: One hundred twenty-one participants, aged 12 through 18 years, with DSM-IV diagnosis of anorexia nervosa excluding the amenorrhea requirement. Intervention Twenty-four outpatient hours of treatment over 12 months of FBT or AFT. Participants were assessed at baseline, end of treatment (EOT), and 6 months' and 12 months' follow-up posttreatment. MAIN OUTCOME MEASURES: Full remission from anorexia nervosa defined as normal weight (≥95% of expected for sex, age, and height) and mean global Eating Disorder Examination score within 1 SD of published means. Secondary outcome measures included partial remission rates (>85% of expected weight for height plus those who were in full remission) and changes in body mass index percentile and eating-related psychopathology. RESULTS: There were no differences in full remission between treatments at EOT. However, at both the 6- and 12-month follow-up, FBT was significantly superior to AFT on this measure. Family-based treatment was significantly superior for partial remission at EOT but not at follow-up. In addition, body mass index percentile at EOT was significantly superior for FBT, but this effect was not found at follow-up. Participants in FBT also had greater changes in Eating Disorder Examination score at EOT than those in AFT, but there were no differences at follow-up. CONCLUSION: Although both treatments led to considerable improvement and were similarly effective in producing full remission at EOT, FBT was more effective in facilitating full remission at both follow-up points. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00149786.
RCT Entities:
CONTEXT: Evidence-based treatment trials for adolescents with anorexia nervosa are few. OBJECTIVE: To evaluate the relative efficacy of family-based treatment (FBT) and adolescent-focused individual therapy (AFT) for adolescents with anorexia nervosa in full remission. DESIGN: Randomized controlled trial. SETTING: Stanford University and The University of Chicago (April 2005 until March 2009). PARTICIPANTS: One hundred twenty-one participants, aged 12 through 18 years, with DSM-IV diagnosis of anorexia nervosa excluding the amenorrhea requirement. Intervention Twenty-four outpatient hours of treatment over 12 months of FBT or AFT. Participants were assessed at baseline, end of treatment (EOT), and 6 months' and 12 months' follow-up posttreatment. MAIN OUTCOME MEASURES: Full remission from anorexia nervosa defined as normal weight (≥95% of expected for sex, age, and height) and mean global Eating Disorder Examination score within 1 SD of published means. Secondary outcome measures included partial remission rates (>85% of expected weight for height plus those who were in full remission) and changes in body mass index percentile and eating-related psychopathology. RESULTS: There were no differences in full remission between treatments at EOT. However, at both the 6- and 12-month follow-up, FBT was significantly superior to AFT on this measure. Family-based treatment was significantly superior for partial remission at EOT but not at follow-up. In addition, body mass index percentile at EOT was significantly superior for FBT, but this effect was not found at follow-up. Participants in FBT also had greater changes in Eating Disorder Examination score at EOT than those in AFT, but there were no differences at follow-up. CONCLUSION: Although both treatments led to considerable improvement and were similarly effective in producing full remission at EOT, FBT was more effective in facilitating full remission at both follow-up points. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00149786.
Authors: Hans W Hoek; Peter N van Harten; Karin M E Hermans; Melanie A Katzman; Glenn E Matroos; Ezra S Susser Journal: Am J Psychiatry Date: 2005-04 Impact factor: 18.112
Authors: Lisa Brownstone; Kristen Anderson; Judy Beenhakker; James Lock; Daniel Le Grange Journal: Int J Eat Disord Date: 2012-03-12 Impact factor: 4.861
Authors: James Lock; Daniel Le Grange; W Stewart Agras; Kathleen Kara Fitzpatrick; Booil Jo; Erin Accurso; Sarah Forsberg; Kristen Anderson; Kate Arnow; Maya Stainer Journal: Behav Res Ther Date: 2015-08-01
Authors: Erin C Accurso; Ellen Astrachan-Fletcher; Setareh O'Brien; Susan F McClanahan; Daniel Le Grange Journal: Eat Disord Date: 2017-06-01 Impact factor: 3.222