Literature DB >> 2092083

Experimental design based 3-D QSAR analysis of steroid-protein interactions: application to human CBG complexes.

U Norinder1.   

Abstract

An experimental design based 3-D QSAR analysis using a combination of principal component and PLS analysis is presented and applied to human corticosteroid-binding globulin complexes. The predictive capability of the created model is good. The technique can also be used as guidance when selecting new compounds to be investigated.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2092083     DOI： 10.1007/BF00117403

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN： 0920-654X            Impact factor:   3.686


  3 in total

1.  Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins.

Authors:  R D Cramer; D E Patterson; J D Bunce
Journal:  J Am Chem Soc       Date:  1988-08-01       Impact factor: 15.419

2.  Analysis of the in vitro antiviral activity of certain ribonucleosides against parainfluenza virus using a novel computer aided receptor modeling procedure.

Authors:  A K Ghose; G M Crippen; G R Revankar; P A McKernan; D F Smee; R K Robins
Journal:  J Med Chem       Date:  1989-04       Impact factor: 7.446

3.  Steroid-protein interactions. Human corticosteroid binding globulin: some physicochemical properties and binding specificity.

Authors:  K E Mickelson; J Forsthoefel; U Westphal
Journal:  Biochemistry       Date:  1981-10-13       Impact factor: 3.162
  3 in total
  7 in total

1.  PLS modelling of structure-activity relationships of catechol O-methyltransferase inhibitors.

Authors:  T Lotta; J Taskinen; R Bäckström; E Nissinen
Journal:  J Comput Aided Mol Des       Date:  1992-06       Impact factor: 3.686

2.  HINT: a new method of empirical hydrophobic field calculation for CoMFA.

Authors:  G E Kellogg; S F Semus; D J Abraham
Journal:  J Comput Aided Mol Des       Date:  1991-12       Impact factor: 3.686

3.  3-D QSAR analysis of steroid/protein interactions: the use of difference maps.

Authors:  U Norinder
Journal:  J Comput Aided Mol Des       Date:  1991-10       Impact factor: 3.686

4.  Objective models for steroid binding sites of human globulins.

Authors:  J Schnitker; R Gopalaswamy; G M Crippen
Journal:  J Comput Aided Mol Des       Date:  1997-01       Impact factor: 3.686

5.  The effect of physical organic properties on hydrophobic fields.

Authors:  D J Abraham; G E Kellogg
Journal:  J Comput Aided Mol Des       Date:  1994-02       Impact factor: 3.686

6.  Drug design for ever, from hype to hope.

Authors:  G Seddon; V Lounnas; R McGuire; T van den Bergh; R P Bywater; L Oliveira; G Vriend
Journal:  J Comput Aided Mol Des       Date:  2012-01-18       Impact factor: 3.686

7.  A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis.

Authors:  Charles Okeke Nnadi; Julia Barbara Althaus; Ngozi Justina Nwodo; Thomas Jürgen Schmidt
Journal:  Molecules       Date:  2018-05-08       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.