Literature DB >> 20920778

IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist.

Rebecca E Slager, Gregory A Hawkins, Elizabeth J Ampleford, Alexandra Bowden, Lauren E Stevens, Matthew T Morton, Adrian Tomkinson, Sally E Wenzel, Malinda Longphre, Eugene R Bleecker, Deborah A Meyers.   

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Year:  2010        PMID： 20920778      PMCID： PMC3772526          DOI： 10.1016/j.jaci.2010.08.001

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


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  9 in total

1.  IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma.

Authors:  Michael Kabesch; Michaela Schedel; David Carr; Bernd Woitsch; Christian Fritzsch; Stephan K Weiland; Erika von Mutius
Journal:  J Allergy Clin Immunol       Date:  2006-02       Impact factor: 10.793

2.  IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression.

Authors:  Sally E Wenzel; Silvana Balzar; Elizabeth Ampleford; Gregory A Hawkins; William W Busse; William J Calhoun; Mario Castro; K Fan Chung; Serpil Erzurum; Benjamin Gaston; Elliot Israel; W Gerald Teague; Douglas Curran-Everett; Deborah A Meyers; Eugene R Bleecker
Journal:  Am J Respir Crit Care Med       Date:  2006-12-14       Impact factor: 21.405

Review 3.  Genetics of IL-13 and functional relevance of IL-13 variants.

Authors:  Donata Vercelli
Journal:  Curr Opin Allergy Clin Immunol       Date:  2002-10

4.  The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.

Authors:  G K Hershey; M F Friedrich; L A Esswein; M L Thomas; T A Chatila
Journal:  N Engl J Med       Date:  1997-12-11       Impact factor: 91.245

5.  Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.

Authors:  Timothy D Howard; Gerard H Koppelman; Jianfeng Xu; Siqun L Zheng; Dirkje S Postma; Deborah A Meyers; Eugene R Bleecker
Journal:  Am J Hum Genet       Date:  2001-11-14       Impact factor: 11.025

6.  Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.

Authors:  T D Howard; P A Whittaker; A L Zaiman; G H Koppelman; J Xu; M T Hanley; D A Meyers; D S Postma; E R Bleecker
Journal:  Am J Respir Cell Mol Biol       Date:  2001-09       Impact factor: 6.914

7.  Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies.

Authors:  Sally Wenzel; Darren Wilbraham; Rick Fuller; Elise Burmeister Getz; Malinda Longphre
Journal:  Lancet       Date:  2007-10-20       Impact factor: 79.321

8.  Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma.

Authors:  A Tomkinson; J Tepper; M Morton; A Bowden; L Stevens; P Harris; D Lindell; N Fitch; R Gundel; E B Getz
Journal:  Allergy       Date:  2009-10-01       Impact factor: 13.146

9.  Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.

Authors:  Raffi Tachdjian; Clinton Mathias; Shadi Al Khatib; Paul J Bryce; Hong S Kim; Frank Blaeser; Brian D O'Connor; Danuta Rzymkiewicz; Andrew Chen; Michael J Holtzman; Gurjit K Hershey; Holger Garn; Hani Harb; Harald Renz; Hans C Oettgen; Talal A Chatila
Journal:  J Exp Med       Date:  2009-09-21       Impact factor: 14.307
  9 in total
  19 in total

Review 1.  Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes.

Authors:  Andrew L Kau; Phillip E Korenblat
Journal:  Curr Opin Allergy Clin Immunol       Date:  2014-12

Review 2.  Asthma phenotypes: the evolution from clinical to molecular approaches.

Authors:  Sally E Wenzel
Journal:  Nat Med       Date:  2012-05-04       Impact factor: 53.440

Review 3.  Genetics of asthma and allergy: what have we learned?

Authors:  Deborah A Meyers
Journal:  J Allergy Clin Immunol       Date:  2010-09       Impact factor: 10.793

Review 4.  Toward precision medicine and health: Opportunities and challenges in allergic diseases.

Authors:  Stephen Joseph Galli
Journal:  J Allergy Clin Immunol       Date:  2016-05       Impact factor: 10.793

Review 5.  IL-4 and IL-13 signaling in allergic airway disease.

Authors:  Naina Gour; Marsha Wills-Karp
Journal:  Cytokine       Date:  2015-06-09       Impact factor: 3.861

6.  IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.

Authors:  Rebecca E Slager; Babatunde A Otulana; Gregory A Hawkins; Yu Ping Yen; Stephen P Peters; Sally E Wenzel; Deborah A Meyers; Eugene R Bleecker
Journal:  J Allergy Clin Immunol       Date:  2012-04-26       Impact factor: 10.793

7.  IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.

Authors:  Marcus J Robinson; Melanie Prout; Helen Mearns; Ryan Kyle; Mali Camberis; Elizabeth E Forbes-Blom; William E Paul; Christopher D C Allen; Graham Le Gros
Journal:  J Immunol       Date:  2017-01-23       Impact factor: 5.422

8.  Interleukin 13 and the evolution of asthma therapy.

Authors:  Gabriele Grünig; David B Corry; Joan Reibman; Marsha Wills-Karp
Journal:  Am J Clin Exp Immunol       Date:  2012-06-30

Review 9.  Pharmacogenetics and the development of personalized approaches for combination therapy in asthma.

Authors:  Stacey M Miller; Victor E Ortega
Journal:  Curr Allergy Asthma Rep       Date:  2013-10       Impact factor: 4.806

Review 10.  A molecular perspective on TH2-promoting cytokine receptors in patients with allergic disease.

Authors:  Martin J Romeo; Rachana Agrawal; Anna Pomés; Judith A Woodfolk
Journal:  J Allergy Clin Immunol       Date:  2013-09-29       Impact factor: 10.793
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