Literature DB >> 2091339

Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in semi-immune children in Zaria, northern Nigeria.

L Lege-Oguntoye1, S I Adagu, B Werblinska, W N Ogala, A B Slotboom.   

Abstract

The World Health Organization (WHO) extended field test was employed to assess the in vivo sensitivity of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in 44 children in Zaria urban area. 36 children (82%) were fully sensitive to the drug and 8 (18%) were resistant at the RI level. 8 parasite isolates were obtained from the children and successfully cultured in vitro using the WHO microtest (mark II) system. The 8 isolates underwent schizogony at concentrations of 10,000 pmol sulfadoxine/125 pmol pyrimethamine per well, indicating in vitro resistance.

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Year:  1990        PMID： 2091339     DOI： 10.1016/0035-9203(90)90016-8

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  3 in total

1.  The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria.

Authors:  P A Winstanley; W M Watkins; C R Newton; C Nevill; E Mberu; P A Warn; C M Waruiru; I N Mwangi; D A Warrell; K Marsh
Journal:  Br J Clin Pharmacol       Date:  1992-02       Impact factor: 4.335

2.  Effects of pyrimethamine versus proguanil in malarial chemoprophylaxis in children with sickle cell disease: a randomized, placebo-controlled, open-label study.

Authors:  Felicia U Eke; Ifeoma Anochie
Journal:  Curr Ther Res Clin Exp       Date:  2003-09

3.  In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs.

Authors:  P A Winstanley; E K Mberu; I S Szwandt; A M Breckenridge; W M Watkins
Journal:  Antimicrob Agents Chemother       Date:  1995-04       Impact factor: 5.191
  3 in total

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