| Literature DB >> 209007 |
O Makabe, A Miyadera, M Kinoshita, S Umezawa.
Abstract
The syntheses of N1- and N2-isopropylformycin (10, 11), formycin 3',5'-cyclic and 2',3'-cyclic phosphate (3,7) and their N-methyl and N-isopropyl derivatives (13, 15, 19, 23) are described. It was observed that substitution at N1 or N2 with a bulky alkyl group or cyclic phosphorylation of the ribose moiety made formycin resistant to adenosine deaminase.Entities:
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Year: 1978 PMID： 209007 DOI： 10.7164/antibiotics.31.456
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649