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Literature DB >> 20890120

Skeletal aging and the adipocyte program: New insights from an "old" molecule.

Beata Lecka-Czernik¹, Clifford J Rosen, Masanobu Kawai.

Abstract

Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging.

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Year: 2010 PMID： 20890120 PMCID： PMC3047793 DOI： 10.4161/cc.9.18.13046

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

69 in total

1. Leptin regulates bone formation via the sympathetic nervous system.

Authors: Shu Takeda; Florent Elefteriou; Regis Levasseur; Xiuyun Liu; Liping Zhao; Keith L Parker; Dawna Armstrong; Patricia Ducy; Gerard Karsenty
Journal: Cell Date: 2002-11-01 Impact factor: 41.582

2. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.

Authors: M Tucker; M A Valencia-Sanchez; R R Staples; J Chen; C L Denis; R Parker
Journal: Cell Date: 2001-02-09 Impact factor: 41.582

3. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways.

Authors: Yusuke Shinoda; Masayuki Yamaguchi; Naoshi Ogata; Toru Akune; Naoto Kubota; Toshimasa Yamauchi; Yasuo Terauchi; Takashi Kadowaki; Yasuhiro Takeuchi; Seiji Fukumoto; Toshiyuki Ikeda; Kazuto Hoshi; Ung-il Chung; Kozo Nakamura; Hiroshi Kawaguchi
Journal: J Cell Biochem Date: 2006-09-01 Impact factor: 4.429

4. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice.

Authors: S X Cao; J M Dhahbi; P L Mote; S R Spindler
Journal: Proc Natl Acad Sci U S A Date: 2001-09-04 Impact factor: 11.205

5. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast.

Authors: Kazuya Oshima; Akihide Nampei; Morihiro Matsuda; Masanori Iwaki; Atsunori Fukuhara; Jun Hashimoto; Hideki Yoshikawa; Iichiro Shimomura
Journal: Biochem Biophys Res Commun Date: 2005-06-03 Impact factor: 3.575

6. Circulating levels of IGF-1 directly regulate bone growth and density.

Authors: Shoshana Yakar; Clifford J Rosen; Wesley G Beamer; Cheryl L Ackert-Bicknell; Yiping Wu; Jun-Li Liu; Guck T Ooi; Jennifer Setser; Jan Frystyk; Yves R Boisclair; Derek LeRoith
Journal: J Clin Invest Date: 2002-09 Impact factor: 14.808

7. How to track cellular aging of mesenchymal stromal cells?

Authors: Wolfgang Wagner; Simone Bork; Günther Lepperdinger; Sylvia Joussen; Nan Ma; Dirk Strunk; Carmen Koch
Journal: Aging (Albany NY) Date: 2010-04 Impact factor: 5.682

8. Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1.

Authors: Bianca Maria Scicchitano; Emanuele Rizzuto; Antonio Musarò
Journal: Aging (Albany NY) Date: 2009-05-13 Impact factor: 5.682

9. Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone).

Authors: V Sottile; K Seuwen; M Kneissel
Journal: Calcif Tissue Int Date: 2004-07-13 Impact factor: 4.333

10. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.

Authors: Olaia Naveiras; Valentina Nardi; Pamela L Wenzel; Peter V Hauschka; Frederic Fahey; George Q Daley
Journal: Nature Date: 2009-06-10 Impact factor: 49.962

29 in total

1. ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b.

Authors: Luca Vanella; Ming Li; DongHyun Kim; Giuseppe Malfa; Lars Bellner; Tomoko Kawakami; Nader G Abraham
Journal: Cell Cycle Date: 2012-02-15 Impact factor: 4.534

Review 2. The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity.

Authors: H Sadie-Van Gijsen; N J Crowther; F S Hough; W F Ferris
Journal: Cell Mol Life Sci Date: 2012-11-21 Impact factor: 9.261

Review 3. Adipose tissue dysfunction and its effects on tumor metabolism.

Authors: Jonathan Diedrich; Halina Chkourko Gusky; Izabela Podgorski
Journal: Horm Mol Biol Clin Investig Date: 2015-01

Review 4. Nocturnin: at the crossroads of clocks and metabolism.

Authors: Jeremy J Stubblefield; Jérémy Terrien; Carla B Green
Journal: Trends Endocrinol Metab Date: 2012-05-17 Impact factor: 12.015

Review 5. Niche heterogeneity in the bone marrow.

Authors: Alexander Birbrair; Paul S Frenette
Journal: Ann N Y Acad Sci Date: 2016-03-25 Impact factor: 5.691

Review 6. Bone marrow fat and the decline of B lymphopoiesis in rabbits.

Authors: Domenick E Kennedy; Pamela L Witte; Katherine L Knight
Journal: Dev Comp Immunol Date: 2015-11-11 Impact factor: 3.636

Review 7. Obesity and bone.

Authors: Juliet Compston
Journal: Curr Osteoporos Rep Date: 2013-03 Impact factor: 5.096

8. Diet and gene interactions influence the skeletal response to polyunsaturated fatty acids.

Authors: Nicolas Bonnet; Emmanuel Somm; Clifford J Rosen
Journal: Bone Date: 2014-08-01 Impact factor: 4.398

9. FOXOs attenuate bone formation by suppressing Wnt signaling.

Authors: Srividhya Iyer; Elena Ambrogini; Shoshana M Bartell; Li Han; Paula K Roberson; Rafael de Cabo; Robert L Jilka; Robert S Weinstein; Charles A O'Brien; Stavros C Manolagas; Maria Almeida
Journal: J Clin Invest Date: 2013-07-15 Impact factor: 14.808

10. Relationship of weight, height, and body mass index with fracture risk at different sites in postmenopausal women: the Global Longitudinal study of Osteoporosis in Women (GLOW).

Authors: Juliet E Compston; Julie Flahive; David W Hosmer; Nelson B Watts; Ethel S Siris; Stuart Silverman; Kenneth G Saag; Christian Roux; Maurizio Rossini; Johannes Pfeilschifter; Jeri W Nieves; J Coen Netelenbos; Lyn March; Andrea Z LaCroix; Frederick H Hooven; Susan L Greenspan; Stephen H Gehlbach; Adolfo Díez-Pérez; Cyrus Cooper; Roland D Chapurlat; Steven Boonen; Frederick A Anderson; Silvano Adami; Jonathan D Adachi
Journal: J Bone Miner Res Date: 2014-02 Impact factor: 6.741