| Literature DB >> 20889127 |
Lillian J Eichner1, Marie-Claude Perry1, Catherine R Dufour2, Nicholas Bertos3, Morag Park4, Julie St-Pierre1, Vincent Giguère5.
Abstract
Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the Warburg effect. miR-378(∗) is embedded within PPARGC1b which encodes PGC-1β, a transcriptional regulator of oxidative energy metabolism. Here we show that miR-378(∗) expression is regulated by ERBB2 and induces a metabolic shift in breast cancer cells. miR-378(∗) performs this function by inhibiting the expression of two PGC-1β partners, ERRγ and GABPA, leading to a reduction in tricarboxylic acid cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation. In situ hybridization experiments show that miR-378(∗) expression correlates with progression of human breast cancer. These results identify miR-378(∗) as a molecular switch involved in the orchestration of the Warburg effect in breast cancer cells via interference with a well-integrated bioenergetics transcriptional pathway.Entities:
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Year: 2010 PMID： 20889127 DOI： 10.1016/j.cmet.2010.09.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287