| Literature DB >> 20888800 |
Ruben S R M Martherus1, Willem Sluiter, Erika D J Timmer, Sabina J V VanHerle, Hubert J M Smeets, Torik A Y Ayoubi.
Abstract
Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) and glioblastoma amplified sequence (GBAS). We predicted both genes to be involved in oxidative phosphorylation. Through in vitro experiments using gene-knockdown we could indeed confirm this and furthermore we asserted CHCHD10 to play a role in complex IV activity.Entities:
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Year: 2010 PMID： 20888800 DOI： 10.1016/j.bbrc.2010.09.109
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575