Bo Yu1, Jane Ruman, Gregory Christman. 1. Program in Reproductive and Adult Endocrinology, National Institutes of Health, Bethesda, Maryland 20892, USA. yub4@mail.nih.gov
Abstract
OBJECTIVE: To review the physiologic functions and clinical significance of peripheral GnRH receptors. DESIGN: Literature review. All peer-reviewed journal articles published before 2010 on peripheral GnRH receptors were searched for in the Pubmed database, and relevant findings were summarized. RESULT(S): Peripheral GnRH/GnRH receptor systems may serve as regulators of hCG synthesis and implantation, and play crucial roles in antiproliferation and apoptosis. Currently, GnRH agonists have been used in cancer treatment and ovary protection during chemotherapy, taking advantage of the local direct effect mediated by peripheral GnRH receptors. CONCLUSION(S): The ubiquitous GnRH/GnRH receptor system in human tissues has been shown to have some important physiologic functions. Further research to clarify functions of these peripheral GnRH receptors may lead to discovery of new therapeutic options. Published by Elsevier Inc.
OBJECTIVE: To review the physiologic functions and clinical significance of peripheral GnRH receptors. DESIGN: Literature review. All peer-reviewed journal articles published before 2010 on peripheral GnRH receptors were searched for in the Pubmed database, and relevant findings were summarized. RESULT(S): Peripheral GnRH/GnRH receptor systems may serve as regulators of hCG synthesis and implantation, and play crucial roles in antiproliferation and apoptosis. Currently, GnRH agonists have been used in cancer treatment and ovary protection during chemotherapy, taking advantage of the local direct effect mediated by peripheral GnRH receptors. CONCLUSION(S): The ubiquitous GnRH/GnRH receptor system in human tissues has been shown to have some important physiologic functions. Further research to clarify functions of these peripheral GnRH receptors may lead to discovery of new therapeutic options. Published by Elsevier Inc.
Authors: Sung Hwan Cho; Eun Hee Ahn; Hui Jeong An; Ji Hyang Kim; Jung Jae Ko; Young Ran Kim; Woo Sik Lee; Nam Keun Kim Journal: Int J Mol Sci Date: 2017-06-12 Impact factor: 5.923