| Literature DB >> 20888176 |
C O R Júnior1, R O Alves, C A M Rezende, C F da Costa, H Silva, M Le Hyaric, A P S Fontes, R J Alves, A J Romanha, M V de Almeida.
Abstract
Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet.Entities:
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Year: 2010 PMID： 20888176 DOI： 10.1016/j.biopha.2010.06.002
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529