BACKGROUND: Cytokine changes after microwave tissue ablation (MTA) were compared with hepatic resection, cryotherapy (CRYO), and radiofrequency ablation (RFA). Cytokine production was measured at various ablation volumes for each modality and correlated with the transitional inflammatory zone produced by the ablation techniques. METHODS: Live rats underwent MTA, surgical resection, CRYO or RFA of 15%, 33%, or 66% of the total hepatic volume. Serum samples were collected preoperatively and at 1, 3, 6, 24, and 48 hours after surgery and analyzed for pro-inflammatory cytokines interleukin (IL)-1β and IL-6. RESULTS: Significantly higher levels of both cytokines were present after CRYO and RFA compared with MTA, hepatic resection, or controls (P < .001). All animals survived except those undergoing RFA or CRYO of 66% of the hepatic volume, which died within 6 hours. Transitional zones produced after RFA were larger than those after CRYO or MTA, but no correlation was present with the amount of cytokines. CONCLUSIONS: Large-volume MTA is associated with a significant decreased cytokine response and is well tolerated compared with RFA and CRYO.
BACKGROUND: Cytokine changes after microwave tissue ablation (MTA) were compared with hepatic resection, cryotherapy (CRYO), and radiofrequency ablation (RFA). Cytokine production was measured at various ablation volumes for each modality and correlated with the transitional inflammatory zone produced by the ablation techniques. METHODS: Live rats underwent MTA, surgical resection, CRYO or RFA of 15%, 33%, or 66% of the total hepatic volume. Serum samples were collected preoperatively and at 1, 3, 6, 24, and 48 hours after surgery and analyzed for pro-inflammatory cytokines interleukin (IL)-1β and IL-6. RESULTS: Significantly higher levels of both cytokines were present after CRYO and RFA compared with MTA, hepatic resection, or controls (P < .001). All animals survived except those undergoing RFA or CRYO of 66% of the hepatic volume, which died within 6 hours. Transitional zones produced after RFA were larger than those after CRYO or MTA, but no correlation was present with the amount of cytokines. CONCLUSIONS: Large-volume MTA is associated with a significant decreased cytokine response and is well tolerated compared with RFA and CRYO.
Authors: Fateh Ahmad; Gianpiero Gravante; Neil Bhardwaj; Andrew Strickland; Rizwan Basit; Kevin West; Roberto Sorge; Ashley R Dennison; David M Lloyd Journal: J Gastrointest Surg Date: 2010-07-30 Impact factor: 3.452
Authors: Erik Velez; S Nahum Goldberg; Gaurav Kumar; Yuanguo Wang; Svetlana Gourevitch; Jacob Sosna; Tyler Moon; Christopher L Brace; Muneeb Ahmed Journal: Radiology Date: 2016-07-13 Impact factor: 11.105
Authors: Christian Beyer; Nancy A Stearns; Adreas Giessl; Jörg H W Distler; Georg Schett; David S Pisetsky Journal: Innate Immun Date: 2012-02-16 Impact factor: 2.680
Authors: Joseph P Erinjeri; Contessa T Thomas; Alaiksandra Samoilia; Martin Fleisher; Mithat Gonen; Constantinos T Sofocleous; Raymond H Thornton; Robert H Siegelbaum; Anne M Covey; Lynn A Brody; William Alago; Majid Maybody; Karen T Brown; George I Getrajdman; Stephen B Solomon Journal: J Vasc Interv Radiol Date: 2013-04-10 Impact factor: 3.464