Literature DB >> 20887228

Cohorts for the study of HIV‐1-exposed but uninfected individuals: benefits and limitations.

R E Horton1, P J McLaren, K Fowke, J Kimani, T Blake Ball.   

Abstract

Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or "HIV-1-resistant" individuals, a large number of cohorts that include HIV-exposed seronegative (HESN) subjects have been identified globally for the purpose of investigating the genetic, immunologic, and environmental factors that may help alter susceptibility to HIV-1. In this article, in light of the recent International Symposium on Natural Immunity to HIV, we review the characteristics of different groups with respect to their relative risks and briefly summarize the known cohorts that include exposed uninfected subjects worldwide.

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Year:  2010        PMID: 20887228     DOI: 10.1086/655971

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  35 in total

1.  Regulatory T-Cell Activity But Not Conventional HIV-Specific T-Cell Responses Are Associated With Protection From HIV-1 Infection.

Authors:  Laura Pattacini; Jared M Baeten; Katherine K Thomas; Tayler R Fluharty; Pamela M Murnane; Deborah Donnell; Elizabeth Bukusi; Allan Ronald; Nelly Mugo; Jairam R Lingappa; Connie Celum; M Juliana McElrath; Jennifer M Lund
Journal:  J Acquir Immune Defic Syndr       Date:  2016-06-01       Impact factor: 3.731

2.  Differential regulatory T cell activity in HIV type 1-exposed seronegative individuals.

Authors:  Laura Pattacini; Pamela M Murnane; Erin M Kahle; Michael J Bolton; Jeffrey J Delrow; Jairam R Lingappa; Elly Katabira; Deborah Donnell; M Juliana McElrath; Jared M Baeten; Jennifer M Lund
Journal:  AIDS Res Hum Retroviruses       Date:  2013-07-30       Impact factor: 2.205

3.  Highly Human Immunodeficiency Virus-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity.

Authors:  Jennifer A Fulcher; Laura Romas; Jennifer C Hoffman; Julie Elliott; Terry Saunders; Adam D Burgener; Peter A Anton; Otto O Yang
Journal:  AIDS Res Hum Retroviruses       Date:  2017-06-19       Impact factor: 2.205

4.  Testing for risk and protective trends in genetic analyses of HIV acquisition.

Authors:  Janice M Mccarthy; Patrick R Shea; David B Goldstein; Andrew S Allen
Journal:  Biostatistics       Date:  2014-09-29       Impact factor: 5.899

5.  Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals.

Authors:  Ruey-Chyi Su; Aida Sivro; Joshua Kimani; Walter Jaoko; Francis A Plummer; T Blake Ball
Journal:  Blood       Date:  2011-01-03       Impact factor: 22.113

Review 6.  HIV controllers: a multifactorial phenotype of spontaneous viral suppression.

Authors:  Jacques Thèze; Lisa A Chakrabarti; Benoît Vingert; Filippos Porichis; Daniel E Kaufmann
Journal:  Clin Immunol       Date:  2011-08-04       Impact factor: 3.969

7.  Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs.

Authors:  Eveli Kallas; Kristi Huik; Silver Türk; Merit Pauskar; Ene-Ly Jõgeda; Marina Šunina; Tõnis Karki; Don Des Jarlais; Anneli Uusküla; Radko Avi; Irja Lutsar
Journal:  Med Microbiol Immunol       Date:  2015-12-22       Impact factor: 3.402

8.  HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?

Authors:  Juan C Hernandez; Georges St Laurent; Silvio Urcuqui-Inchima
Journal:  Immunol Res       Date:  2016-02       Impact factor: 2.829

9.  Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.

Authors:  Satoru Watanabe; Masayuki Fujino; Yohei Saito; Nursarat Ahmed; Hirotaka Sato; Chie Sugimoto; Tomotaka Okamura; Kenichi Hanaki; Emi E Nakayama; Tatsuo Shioda; Kouji Matsushima; Aftab A Ansari; Francois Villinger; Kazuyasu Mori
Journal:  J Immunol       Date:  2020-08-03       Impact factor: 5.422

Review 10.  Mucosal correlates of protection in HIV-1-exposed sero-negative persons.

Authors:  Ruizhong Shen; Phillip D Smith
Journal:  Am J Reprod Immunol       Date:  2014-01-16       Impact factor: 3.886

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