Literature DB >> 208855

Free radical intermediates produced by autoxidation of 1,8-dihydroxy-9-anthrone (dithranol) in pyridine.

J Martinmaa, L Vanhala, K K Mustakallio.   

Abstract

The autoxidation of the antipsoriatic agent dithranol, monitored by an ESR-spectrometer, proceeds through several free radical intermediates. The initial radical, attacking a bulky spin trapping agent in a sterically comparatively hindered constellation, may be the active therapeutic form of dithranol.

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Year:  1978        PMID： 208855     DOI： 10.1007/bf01939674

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  3 in total

1.  [Antipsoriatic effect of dithranol (anthralin). 1].

Authors:  W Raab
Journal:  Hautarzt       Date:  1975-09       Impact factor: 0.751

2.  Interaction between dithranol and nucleic acids. A possible mechanism for the effect of dithranol on psoriasis.

Authors:  G Swanbeck; N Thyresson
Journal:  Acta Derm Venereol       Date:  1965       Impact factor: 4.437

3.  [The effect of lipoperoxide and dithranol (cignolin) on psoriasis vulgaris].

Authors:  H Meffert; P Reich
Journal:  Dermatol Monatsschr       Date:  1969
  3 in total
  3 in total

1.  Increased anthralin irritation response in vitiliginous skin.

Authors:  W Westerhof; Y Buehre; S Pavel; J D Bos; P K Das; S R Krieg; A H Siddiqui
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017

2.  Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.

Authors:  M Viluksela
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

3.  Toxicological studies with dithranol and its 10-acyl analogues.

Authors:  P T Männistö; D Kirkland; M Viluksela; L Tikkanen
Journal:  Arch Toxicol       Date:  1986-10       Impact factor: 5.153
  3 in total

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