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Literature DB >> 20885421

Turning down the volume on transcriptional noise.

Abstract

Transcriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear whether it is directly controlled. Dig1, a regulator of the budding yeast mating pathway, is now shown to prevent transcriptional noise by regulating the spatial organization of downstream gene targets.

Entities: Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20885421 DOI： 10.1038/ncb1010-929

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

12 in total

1. Stochastic gene expression in a single cell.

Authors: Michael B Elowitz; Arnold J Levine; Eric D Siggia; Peter S Swain
Journal: Science Date: 2002-08-16 Impact factor: 47.728

2. Intrinsic and extrinsic contributions to stochasticity in gene expression.

Authors: Peter S Swain; Michael B Elowitz; Eric D Siggia
Journal: Proc Natl Acad Sci U S A Date: 2002-09-17 Impact factor: 11.205

3. Control of stochasticity in eukaryotic gene expression.

Authors: Jonathan M Raser; Erin K O'Shea
Journal: Science Date: 2004-05-27 Impact factor: 47.728

4. Regulated cell-to-cell variation in a cell-fate decision system.

Authors: Alejandro Colman-Lerner; Andrew Gordon; Eduard Serra; Tina Chin; Orna Resnekov; Drew Endy; C Gustavo Pesce; Roger Brent
Journal: Nature Date: 2005-09-18 Impact factor: 49.962

5. Non-genetic individuality: chance in the single cell.

Authors: J L Spudich; D E Koshland
Journal: Nature Date: 1976-08-05 Impact factor: 49.962

6. Interchromosomal associations between alternatively expressed loci.

Authors: Charalampos G Spilianakis; Maria D Lalioti; Terrence Town; Gap Ryol Lee; Richard A Flavell
Journal: Nature Date: 2005-05-08 Impact factor: 49.962

7. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.

Authors: Stefan Schoenfelder; Tom Sexton; Lyubomira Chakalova; Nathan F Cope; Alice Horton; Simon Andrews; Sreenivasulu Kurukuti; Jennifer A Mitchell; David Umlauf; Daniela S Dimitrova; Christopher H Eskiw; Yanquan Luo; Chia-Lin Wei; Yijun Ruan; James J Bieker; Peter Fraser
Journal: Nat Genet Date: 2009-12-13 Impact factor: 38.330

8. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.

Authors: Emma McCullagh; Anupama Seshan; Hana El-Samad; Hiten D Madhani
Journal: Nat Cell Biol Date: 2010-09-19 Impact factor: 28.824

9. Active genes dynamically colocalize to shared sites of ongoing transcription.

Authors: Cameron S Osborne; Lyubomira Chakalova; Karen E Brown; David Carter; Alice Horton; Emmanuel Debrand; Beatriz Goyenechea; Jennifer A Mitchell; Susana Lopes; Wolf Reik; Peter Fraser
Journal: Nat Genet Date: 2004-09-07 Impact factor: 38.330

10. Negative feedback that improves information transmission in yeast signalling.

Authors: Richard C Yu; C Gustavo Pesce; Alejandro Colman-Lerner; Larry Lok; David Pincus; Eduard Serra; Mark Holl; Kirsten Benjamin; Andrew Gordon; Roger Brent
Journal: Nature Date: 2008-12-11 Impact factor: 49.962

5 in total

Review 1. Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability.

Authors: Prakash Kulkarni; Tsega L Solomon; Yanan He; Yihong Chen; Philip N Bryan; John Orban
Journal: Protein Sci Date: 2018-09-24 Impact factor: 6.725

2. Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.

Authors: Daniel S Neems; Arturo G Garza-Gongora; Erica D Smith; Steven T Kosak
Journal: Proc Natl Acad Sci U S A Date: 2016-03-08 Impact factor: 11.205