Literature DB >> 20885395

The antibacterial lead discovery challenge.

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Year:  2010        PMID： 20885395     DOI： 10.1038/nrd3289

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  5 in total

1.  Type IIA topoisomerase inhibition by a new class of antibacterial agents.

Authors:  Benjamin D Bax; Pan F Chan; Drake S Eggleston; Andrew Fosberry; Daniel R Gentry; Fabrice Gorrec; Ilaria Giordano; Michael M Hann; Alan Hennessy; Martin Hibbs; Jianzhong Huang; Emma Jones; Jo Jones; Kristin Koretke Brown; Ceri J Lewis; Earl W May; Martin R Saunders; Onkar Singh; Claus E Spitzfaden; Carol Shen; Anthony Shillings; Andrew J Theobald; Alexandre Wohlkonig; Neil D Pearson; Michael N Gwynn
Journal:  Nature       Date:  2010-08-04       Impact factor: 49.962

Review 2.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

Review 3.  A decade of fragment-based drug design: strategic advances and lessons learned.

Authors:  Philip J Hajduk; Jonathan Greer
Journal:  Nat Rev Drug Discov       Date:  2007-02-09       Impact factor: 84.694

Review 4.  Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.

Authors:  Helen W Boucher; George H Talbot; John S Bradley; John E Edwards; David Gilbert; Louis B Rice; Michael Scheld; Brad Spellberg; John Bartlett
Journal:  Clin Infect Dis       Date:  2009-01-01       Impact factor: 9.079

5.  Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study.

Authors:  Karthikeyan K Kumarasamy; Mark A Toleman; Timothy R Walsh; Jay Bagaria; Fafhana Butt; Ravikumar Balakrishnan; Uma Chaudhary; Michel Doumith; Christian G Giske; Seema Irfan; Padma Krishnan; Anil V Kumar; Sunil Maharjan; Shazad Mushtaq; Tabassum Noorie; David L Paterson; Andrew Pearson; Claire Perry; Rachel Pike; Bhargavi Rao; Ujjwayini Ray; Jayanta B Sarma; Madhu Sharma; Elizabeth Sheridan; Mandayam A Thirunarayan; Jane Turton; Supriya Upadhyay; Marina Warner; William Welfare; David M Livermore; Neil Woodford
Journal:  Lancet Infect Dis       Date:  2010-08-10       Impact factor: 25.071
  5 in total
  12 in total

1.  Thermodynamic computational approach to capture molecular recognition in the binding of different inhibitors to the DNA gyrase B subunit from Escherichia coli.

Authors:  Liane Saíz-Urra; Miguel Ángel Cabrera Pérez; Matheus Froeyen
Journal:  J Mol Model       Date:  2013-04-30       Impact factor: 1.810

2.  Structure-activity relationships of thiostrepton derivatives: implications for rational drug design.

Authors:  Antje Wolf; Sebastian Schoof; Sascha Baumann; Hans-Dieter Arndt; Karl N Kirschner
Journal:  J Comput Aided Mol Des       Date:  2014-10-04       Impact factor: 3.686

Review 3.  Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria.

Authors:  Hiroshi Nikaido; Jean-Marie Pagès
Journal:  FEMS Microbiol Rev       Date:  2011-07-29       Impact factor: 16.408

4.  Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors.

Authors:  Emilia Caselli; Chiara Romagnoli; Roza Vahabi; Magdalena A Taracila; Robert A Bonomo; Fabio Prati
Journal:  J Med Chem       Date:  2015-07-10       Impact factor: 7.446

5.  Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.

Authors:  Neeraj Dhar; Vincent Dubée; Lluis Ballell; Guillaume Cuinet; Jean-Emmanuel Hugonnet; François Signorino-Gelo; David Barros; Michel Arthur; John D McKinney
Journal:  Antimicrob Agents Chemother       Date:  2014-11-24       Impact factor: 5.191

6.  Single-cell tracking reveals antibiotic-induced changes in mycobacterial energy metabolism.

Authors:  Željka Maglica; Emre Özdemir; John D McKinney
Journal:  MBio       Date:  2015-02-17       Impact factor: 7.867

7.  Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines.

Authors:  Prashant Gahtori; Surajit Kumar Ghosh; Brijesh Singh; Udaya Pratap Singh; Hans Raj Bhat; Archana Uppal
Journal:  Saudi Pharm J       Date:  2011-05-17       Impact factor: 4.330

8.  Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA.

Authors:  Wilko Duprez; Prabhakar Bachu; Martin J Stoermer; Stephanie Tay; Róisín M McMahon; David P Fairlie; Jennifer L Martin
Journal:  PLoS One       Date:  2015-07-30       Impact factor: 3.240

9.  Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity.

Authors:  Ewa Otręebska-Machaj; Jacqueline Chevalier; Jadwiga Handzlik; Ewa Szymańska; Jakub Schabikowski; Gérard Boyer; Jean-Michel Bolla; Katarzyna Kieć-Kononowicz; Jean-Marie Pagès; Sandrine Alibert
Journal:  Front Microbiol       Date:  2016-05-03       Impact factor: 5.640

10.  Fluoroquinolone structure and translocation flux across bacterial membrane.

Authors:  Julia Vergalli; Estelle Dumont; Bertrand Cinquin; Laure Maigre; Jelena Pajovic; Eric Bacqué; Michael Mourez; Matthieu Réfrégiers; Jean-Marie Pagès
Journal:  Sci Rep       Date:  2017-08-29       Impact factor: 4.379
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