BACKGROUND: Decline in social functioning occurs in individuals who later develop psychosis. AIMS: To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition. METHOD: Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS-II). RESULTS: At baseline, the transition group displayed significantly greater difficulties in making new friends (z = -3.40, P = 0.001), maintaining a friendship (z =-3.00, P = 0.003), dealing with people they do not know (z =-2.28, P = 0.023) and joining community activities (z =-2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (β = 0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238-2.550). CONCLUSIONS: Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.
BACKGROUND: Decline in social functioning occurs in individuals who later develop psychosis. AIMS: To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition. METHOD: Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS-II). RESULTS: At baseline, the transition group displayed significantly greater difficulties in making new friends (z = -3.40, P = 0.001), maintaining a friendship (z =-3.00, P = 0.003), dealing with people they do not know (z =-2.28, P = 0.023) and joining community activities (z =-2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (β = 0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238-2.550). CONCLUSIONS: Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.
Authors: Dina Collip; Johanna T W Wigman; Ashleigh Lin; Barnaby Nelson; Margreet Oorschot; Wilma A M Vollebergh; Jaymee Ryan; Gennedy Baksheev; Marieke Wichers; Jim van Os; Inez Myin-Germeys; Alison R Yung Journal: Schizophr Bull Date: 2011-09-19 Impact factor: 9.306
Authors: Barbara A Cornblatt; Ricardo E Carrión; Jean Addington; Larry Seidman; Elaine F Walker; Tyronne D Cannon; Kristin S Cadenhead; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Scott W Woods; Robert Heinssen; Todd Lencz Journal: Schizophr Bull Date: 2011-11-10 Impact factor: 9.306
Authors: Barbara A Cornblatt; Ricardo E Carrión; Andrea Auther; Danielle McLaughlin; Ruth H Olsen; Majnu John; Christoph U Correll Journal: Am J Psychiatry Date: 2015-06-05 Impact factor: 18.112
Authors: Danielle McLaughlin; Ricardo E Carrión; Andrea M Auther; Doreen M Olvet; Jean Addington; Carrie E Bearden; Kristin S Cadenhead; Tyrone D Cannon; Robert K Heinssen; Daniel H Mathalon; Thomas H McGlashan; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Scott W Woods; Terry E Goldberg; Philip D Harvey; Barbara A Cornblatt Journal: Schizophr Bull Date: 2016-04-22 Impact factor: 9.306
Authors: A Masillo; L R Valmaggia; R Saba; M Brandizzi; J F Lindau; A Solfanelli; M Curto; F Narilli; L Telesforo; G D Kotzalidis; D Di Pietro; M D'Alema; P Girardi; P Fiori Nastro Journal: Eur Child Adolesc Psychiatry Date: 2015-02-25 Impact factor: 4.785
Authors: Daniel Fulford; Tara A Niendam; Erin G Floyd; Cameron S Carter; Daniel H Mathalon; Sophia Vinogradov; Barbara K Stuart; Rachel L Loewy Journal: Schizophr Res Date: 2013-04-12 Impact factor: 4.939