OBJECTIVE: To examine the difference between patients with normal and patients with abnormal fatigue on aspects of health status, and investigate the natural course of fatigue in patients with Chronic Obstructive Pulmonary Disease (COPD). METHODS: Fatigue, physiological functioning, functional impairment, symptoms, and Quality of Life (QoL) were measured in 168 patients with COPD, and longitudinal data on fatigue of 77 patients were collected. RESULTS: Fifty percent of patients had abnormal fatigue. Patients with abnormal fatigue reported significantly more problems on the sub-domains of functional impairment (except actual physical activity), symptoms, and QoL as compared to patients with normal fatigue. With respect to physiological functioning patients with normal fatigue scores had better exercise capacity. Four years later the percentage of patients with abnormal fatigue was increased to 64%. In 1/3 of the patients an increase of more than the minimal clinically important difference was found. CONCLUSION: Many COPD patients suffer from abnormal fatigue. Patients with abnormal fatigue have more limitations on many aspects of health status, especially on symptoms, functional impairment, and QoL. PRACTICE IMPLICATIONS: Fatigue should be evaluated in usual care with a questionnaire that corrects for normal fatigue in order to tailor treatment to patients' need.
OBJECTIVE: To examine the difference between patients with normal and patients with abnormal fatigue on aspects of health status, and investigate the natural course of fatigue in patients with Chronic Obstructive Pulmonary Disease (COPD). METHODS: Fatigue, physiological functioning, functional impairment, symptoms, and Quality of Life (QoL) were measured in 168 patients with COPD, and longitudinal data on fatigue of 77 patients were collected. RESULTS: Fifty percent of patients had abnormal fatigue. Patients with abnormal fatigue reported significantly more problems on the sub-domains of functional impairment (except actual physical activity), symptoms, and QoL as compared to patients with normal fatigue. With respect to physiological functioning patients with normal fatigue scores had better exercise capacity. Four years later the percentage of patients with abnormal fatigue was increased to 64%. In 1/3 of the patients an increase of more than the minimal clinically important difference was found. CONCLUSION: Many COPDpatients suffer from abnormal fatigue. Patients with abnormal fatigue have more limitations on many aspects of health status, especially on symptoms, functional impairment, and QoL. PRACTICE IMPLICATIONS: Fatigue should be evaluated in usual care with a questionnaire that corrects for normal fatigue in order to tailor treatment to patients' need.
Authors: Roy Meys; Anouk A F Stoffels; Jana de Brandt; Hieronymus W H van Hees; Frits M E Franssen; Maurice J H Sillen; Emiel F M Wouters; Chris Burtin; Peter Klijn; Eline Bij de Vaate; Bram van den Borst; Jacqueline M Otker; Jos Donkers; Florence N Schleich; Maurice Hayot; Pascal Pomiès; Inge Everaert; Wim Derave; Martijn A Spruit Journal: BMJ Open Date: 2020-09-13 Impact factor: 2.692
Authors: Maarten Van Herck; Jeanine Antons; Jan H Vercoulen; Yvonne M J Goërtz; Zjala Ebadi; Chris Burtin; Daisy J A Janssen; Melissa S Y Thong; Jacqueline Otker; Arnold Coors; Mirjam A G Sprangers; Jean W M Muris; Judith B Prins; Martijn A Spruit; Jeannette B Peters Journal: J Clin Med Date: 2019-08-20 Impact factor: 4.241
Authors: Yvonne M J Goërtz; Martijn A Spruit; Alex J Van 't Hul; Jeannette B Peters; Maarten Van Herck; Nienke Nakken; Remco S Djamin; Chris Burtin; Melissa S Y Thong; Arnold Coors; Yvonne Meertens-Kerris; Emiel F M Wouters; Judith B Prins; Frits M E Franssen; Jean W M Muris; Lowie E G W Vanfleteren; Mirjam A G Sprangers; Daisy J A Janssen; Jan H Vercoulen Journal: Ther Adv Respir Dis Date: 2019 Jan-Dec Impact factor: 4.031
Authors: Ada E M Bloem; Rémy L M Mostard; Naomi Stoot; Jan H Vercoulen; Jeannette B Peters; Daisy J A Janssen; Jan W H Custers; Martijn A Spruit Journal: J Clin Med Date: 2020-04-20 Impact factor: 4.241
Authors: Yvonne M J Goërtz; Milou Looijmans; Judith B Prins; Daisy J A Janssen; Melissa S Y Thong; Jeannette B Peters; Chris Burtin; Yvonne Meertens-Kerris; Arnold Coors; Jean W M Muris; Mirjam A G Sprangers; Emiel F M Wouters; Jan H Vercoulen; Martijn A Spruit Journal: BMJ Open Date: 2018-04-10 Impact factor: 2.692
Authors: Susan E Yount; Charles Atwood; James Donohue; Ron D Hays; Debra Irwin; Nancy Kline Leidy; Honghu Liu; Karen L Spritzer; Darren A DeWalt Journal: J Patient Rep Outcomes Date: 2019-10-29