Literature DB >> 20884085

Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

René Csuk1, Stefan Schwarz, Ralph Kluge, Dieter Ströhl.   

Abstract

Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The most compound 7 possesses an aminohexyl side chain, induces apoptosis and shows IC50 values of 0.6-3.0 μM.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20884085     DOI： 10.1016/j.ejmech.2010.09.028

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Induction of apoptosis with mitochondrial membrane depolarization by a glycyrrhetinic acid derivative in human leukemia K562 cells.

Authors:  Zhenbei Gao; Xiao Kang; Jun Hu; Yong Ju; Chuanlian Xu
Journal:  Cytotechnology       Date:  2012-01-25       Impact factor: 2.058

2.  Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species.

Authors:  Mohamed A Farag; Andrea Porzel; Ludger A Wessjohann
Journal:  J Adv Res       Date:  2014-05-14       Impact factor: 10.479

3.  Exploring New Structural Features of the 18β-Glycyrrhetinic Acid Scaffold for the Inhibition of Anaplastic Lymphoma Kinase.

Authors:  Dong Cai; ZhiHua Zhang; Yu Chen; YanYan Zhang; YuQi Sun; YiXia Gong
Journal:  Molecules       Date:  2019-10-08       Impact factor: 4.411

Review 4.  From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues.

Authors:  Oxana Kazakova; Gulnara Giniyatullina; Denis Babkov; Zdenek Wimmer
Journal:  Int J Mol Sci       Date:  2022-01-19       Impact factor: 5.923

5.  Design, synthesis and biological evaluation of novel amide-linked 18β-glycyrrhetinic acid derivatives as novel ALK inhibitors.

Authors:  Dong Cai; Zhi Hua Zhang; Yu Chen; Chao Ruan; Sheng Qiang Li; Shi Qin Chen; Lian Shan Chen
Journal:  RSC Adv       Date:  2020-03-23       Impact factor: 4.036

6.  Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer.

Authors:  George R Pettit; Noeleen Melody; Frank Hempenstall; Jean-Charles Chapuis; Thomas L Groy; Lee Williams
Journal:  J Nat Prod       Date:  2014-04-02       Impact factor: 4.050

Review 7.  An Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents.

Authors:  Bing Xu; Gao-Rong Wu; Xin-Yu Zhang; Meng-Meng Yan; Rui Zhao; Nan-Nan Xue; Kang Fang; Hui Wang; Meng Chen; Wen-Bo Guo; Peng-Long Wang; Hai-Min Lei
Journal:  Molecules       Date:  2017-06-02       Impact factor: 4.411
  7 in total

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