BACKGROUND: Sporotrichosis is the most common subcutaneous mycosis in Rio de Janeiro. Histopathological examination reveals diffuse granulomatous and suppurative dermatitis, and the fungus is rarely identifiable in tissue. We describe the histopathological features of cutaneous sporotrichosis, and investigate the association between them and the lack of visualization of the fungus. METHODS: A total of 119 samples of confirmed sporotrichosis cases were studied. The characteristics of the inflammatory infiltrate, the presence of epidermal changes, necrosis and fibrosis, and the parasite burden were analyzed. The association between histopathological changes and the lack of visualization of the fungus was evaluated using prevalence ratios. RESULTS: Granulomas were observed in all samples, suppurative granulomas in 100 (84%) and diffuse dermatitis in 114 (95.8%). Liquefaction and caseous necrosis were present in 78 (65.5%) and 52 (43.7%) samples, respectively. The fungus was not seen in 77 (64.7%) samples. Epithelioid, tuberculoid or foreign-body-type granulomas, caseous, fibrinoid or absent necrosis, predominance of lymphocytes among nonphagocytic cells and fibrosis were associated with the lack of visualization of the fungus. CONCLUSION: The histopathological characteristics of sporotrichosis were variable when the causative fungus was not seen. In a proper context, the diagnosis of sporotrichosis remains a potential consideration even in the absence of demonstrable yeast.
BACKGROUND: Sporotrichosis is the most common subcutaneous mycosis in Rio de Janeiro. Histopathological examination reveals diffuse granulomatous and suppurative dermatitis, and the fungus is rarely identifiable in tissue. We describe the histopathological features of cutaneous sporotrichosis, and investigate the association between them and the lack of visualization of the fungus. METHODS: A total of 119 samples of confirmed sporotrichosis cases were studied. The characteristics of the inflammatory infiltrate, the presence of epidermal changes, necrosis and fibrosis, and the parasite burden were analyzed. The association between histopathological changes and the lack of visualization of the fungus was evaluated using prevalence ratios. RESULTS:Granulomas were observed in all samples, suppurative granulomas in 100 (84%) and diffuse dermatitis in 114 (95.8%). Liquefaction and caseous necrosis were present in 78 (65.5%) and 52 (43.7%) samples, respectively. The fungus was not seen in 77 (64.7%) samples. Epithelioid, tuberculoid or foreign-body-type granulomas, caseous, fibrinoid or absent necrosis, predominance of lymphocytes among nonphagocytic cells and fibrosis were associated with the lack of visualization of the fungus. CONCLUSION: The histopathological characteristics of sporotrichosis were variable when the causative fungus was not seen. In a proper context, the diagnosis of sporotrichosis remains a potential consideration even in the absence of demonstrable yeast.
Authors: Rosane Orofino-Costa; Dayvison Francis Saraiva Freitas; Andréa Reis Bernardes-Engemann; Anderson Messias Rodrigues; Carolina Talhari; Claudia Elise Ferraz; John Verrinder Veasey; Leonardo Quintella; Maria Silvia Laborne Alves de Sousa; Rodrigo Vettorato; Rodrigo de Almeida-Paes; Priscila Marques de Macedo Journal: An Bras Dermatol Date: 2022-09-22 Impact factor: 2.113
Authors: Rosane Orofino-Costa; Priscila Marques de Macedo; Anderson Messias Rodrigues; Andréa Reis Bernardes-Engemann Journal: An Bras Dermatol Date: 2017 Sep-Oct Impact factor: 1.896
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Authors: Isis Cristine Morávia Ribeiro de Oliveira-Esteves; Guilherme Almeida Rosa da Silva; Walter de Araujo Eyer-Silva; Rodrigo Panno Basílio-de-Oliveira; Luciana Ferreira de Araujo; Carlos José Martins; Rogério Neves-Motta; Marcelo Costa Velho Mendes de Azevedo; Dario José Hart Pontes Signorini; Jorge Francisco da Cunha Pinto; Lívia Machado Moura; Rafael Jacyntho Laterça; Diogo Raphael Garcia de Oliveira Pereira; Isabela Vieira do Lago; Fernando Raphael de Almeida Ferry Journal: Case Rep Infect Dis Date: 2017-09-25
Authors: Thiago Jeunon; Palmira Assis de Jesus Barreto Rodrigues; Thiara Cristina Guimarães Rocha; Marina de Oliveira Bezerra; Maria Clara Gutierrez Galhardo; Antônio Carlos Francesconi do Valle Journal: Dermatol Pract Concept Date: 2013-07-31