Literature DB >> 20882135

Cardiac and cognitive effects of androgen deprivation therapy: are they real?

S M H Alibhai1, H Z Mohamedali.   

Abstract

With androgen deprivation therapy being used ever earlier and longer in the course of prostate cancer, concerns have emerged about a variety of adverse effects, including cardiovascular disease and cognitive dysfunction. Conflicting data in both areas have led to controversy and confusion. Here, we review published data in an attempt to clarify those issues.

Entities:  

Keywords:  Prostatic neoplasms; adverse effects; androgen deprivation therapy; cardiac disease; cognition

Year:  2010        PMID： 20882135      PMCID： PMC2935712          DOI： 10.3747/co.v17i0.709

Source DB:  PubMed          Journal:  Curr Oncol        ISSN： 1198-0052            Impact factor:   3.677


  50 in total

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Authors:  Matthew R Smith; Hang Lee; David M Nathan
Journal:  J Clin Endocrinol Metab       Date:  2006-01-24       Impact factor: 5.958

2.  Effects of the luteinizing hormone-releasing hormone agonist leuprolide on lipoproteins, fibrinogen and plasminogen activator inhibitor in patients with benign prostatic hyperplasia.

Authors:  L M Eri; P Urdal; A G Bechensteen
Journal:  J Urol       Date:  1995-07       Impact factor: 7.450

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Authors:  C L Williams; A M Barnett; W H Meck
Journal:  Behav Neurosci       Date:  1990-02       Impact factor: 1.912

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Authors:  C Huggins; C V Hodges
Journal:  CA Cancer J Clin       Date:  1972 Jul-Aug       Impact factor: 508.702

5.  Androgen deprivation impairs memory in older men.

Authors:  Joseph R Bussiere; Tomasz M Beer; Michelle B Neiss; Jeri S Janowsky
Journal:  Behav Neurosci       Date:  2005-12       Impact factor: 1.912

6.  The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer.

Authors:  J C Smith; S Bennett; L M Evans; H G Kynaston; M Parmar; M D Mason; J R Cockcroft; M F Scanlon; J S Davies
Journal:  J Clin Endocrinol Metab       Date:  2001-09       Impact factor: 5.958

7.  Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: a randomized controlled trial.

Authors:  H J Green; K I Pakenham; B C Headley; J Yaxley; D L Nicol; P N Mactaggart; C E Swanson; R B Watson; R A Gardiner
Journal:  BJU Int       Date:  2004-05       Impact factor: 5.588

8.  Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia.

Authors:  Frances Dockery; Christopher J Bulpitt; Sanjiv Agarwal; Mandy Donaldson; Chakravarthi Rajkumar
Journal:  Clin Sci (Lond)       Date:  2003-02       Impact factor: 6.124

9.  Cardiovascular mortality and duration of androgen deprivation for locally advanced prostate cancer: analysis of RTOG 92-02.

Authors:  Jason A Efstathiou; Kyounghwa Bae; William U Shipley; Gerald E Hanks; Miljenko V Pilepich; Howard M Sandler; Matthew R Smith
Journal:  Eur Urol       Date:  2008-01-15       Impact factor: 20.096

10.  Androgen deprivation and cognition in prostate cancer.

Authors:  E Salminen; R Portin; J Korpela; H Backman; L-M Parvinen; H Helenius; M Nurmi
Journal:  Br J Cancer       Date:  2003-09-15       Impact factor: 7.640
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  4 in total

1.  Testosterone impairs the acquisition of an operant delayed alternation task in male rats.

Authors:  Steven L Neese; Susan L Schantz
Journal:  Horm Behav       Date:  2011-10-25       Impact factor: 3.587

Review 2.  Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients.

Authors:  Lisa M Wu; Ali Amidi
Journal:  Curr Opin Support Palliat Care       Date:  2017-03       Impact factor: 2.302

3.  Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.

Authors:  Padraig Warde; Malcolm Mason; Keyue Ding; Peter Kirkbride; Michael Brundage; Richard Cowan; Mary Gospodarowicz; Karen Sanders; Edmund Kostashuk; Greg Swanson; Jim Barber; Andrea Hiltz; Mahesh K B Parmar; Jinka Sathya; John Anderson; Charles Hayter; John Hetherington; Matthew R Sydes; Wendy Parulekar
Journal:  Lancet       Date:  2011-11-02       Impact factor: 79.321

4.  Protocol for a phase III RCT and economic analysis of two exercise delivery methods in men with PC on ADT.

Authors:  Shabbir M H Alibhai; Paul Ritvo; Daniel Santa Mina; Catherine Sabiston; Murray Krahn; George Tomlinson; Andrew Matthew; Himu Lukka; Padraig Warde; Sara Durbano; Meagan O'Neill; S Nicole Culos-Reed
Journal:  BMC Cancer       Date:  2018-10-23       Impact factor: 4.430
  4 in total

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