BACKGROUND AND AIMS: Leukoaraiosis (LA) is associated with aging and vascular risk factors, and is a risk factor of intracerebral hemorrhage (ICH) after treatment with warfarin or thrombolytic treatment for ischemic stroke. In this study, we sought to examine whether LA is a predictor of outcome after spontaneous ICH. METHODS: We retrospectively analyzed 238 consecutive patients with spontaneous supratentorial ICH identified by a database search. Patients were divided into two groups according to neurological outcome at 90 days: patients with good outcomes (Glasgow Outcome Scale ≥4) and patients with poor outcomes. Demographic features, ICH characteristics, and LA severity as assessed by van Swieten score on brain CT were compared between the two groups. RESULTS: Overall, 105 (44.1%) of the patients analyzed had poor outcomes. In univariate analysis, LA severity, ICH volume on initial brain CT, initial Glasgow Coma Scale (GCS), presence of intraventricular hemorrhage (IVH), old age, surgical treatment, and higher admission serum glucose level were associated with poor outcome. Multiple logistic regression analysis showed that severity of LA, initial GCS score, hematoma volume, presence of IVH, and surgical treatment were independent predictors of poor outcome. CONCLUSION: LA is an independent predictor of poor neurological outcome in patients with spontaneous supratentorial ICH.
BACKGROUND AND AIMS: Leukoaraiosis (LA) is associated with aging and vascular risk factors, and is a risk factor of intracerebral hemorrhage (ICH) after treatment with warfarin or thrombolytic treatment for ischemic stroke. In this study, we sought to examine whether LA is a predictor of outcome after spontaneous ICH. METHODS: We retrospectively analyzed 238 consecutive patients with spontaneous supratentorial ICH identified by a database search. Patients were divided into two groups according to neurological outcome at 90 days: patients with good outcomes (Glasgow Outcome Scale ≥4) and patients with poor outcomes. Demographic features, ICH characteristics, and LA severity as assessed by van Swieten score on brain CT were compared between the two groups. RESULTS: Overall, 105 (44.1%) of the patients analyzed had poor outcomes. In univariate analysis, LA severity, ICH volume on initial brain CT, initial Glasgow Coma Scale (GCS), presence of intraventricular hemorrhage (IVH), old age, surgical treatment, and higher admission serum glucose level were associated with poor outcome. Multiple logistic regression analysis showed that severity of LA, initial GCS score, hematoma volume, presence of IVH, and surgical treatment were independent predictors of poor outcome. CONCLUSION: LA is an independent predictor of poor neurological outcome in patients with spontaneous supratentorial ICH.
Authors: Simone M Uniken Venema; Sandro Marini; Umme K Lena; Andrea Morotti; Michael Jessel; Charles J Moomaw; Christina Kourkoulis; Fernando D Testai; Steven J Kittner; H Bart Brouwers; Michael L James; Daniel Woo; Christopher D Anderson; Jonathan Rosand Journal: Stroke Date: 2019-08-26 Impact factor: 7.914
Authors: Mahesh Kate; Laura Gioia; Thomas Jeerakathil; Michael D Hill; Bronwen Gould; Rebecca McCourt; Dar Dowlatshahi; Shelagh Coutts; Jayme Kosior; Andrew Demchuk; Brian Buck; Kenneth Butcher Journal: PLoS One Date: 2019-03-11 Impact factor: 3.240