Literature DB >> 20880985

Commentary: the year in nuclear receptor control of metabolism.

David J Mangelsdorf1.   

Abstract

This commentary highlights some of the most important discoveries in the field of nuclear receptor control of metabolism that occurred over the past year (2009 to 2010). As might be expected in a field that encompasses several hundred active laboratories, the task of providing a balanced look at these discoveries was daunting. Thus, to help make the selection of these discoveries, a small panel of colleagues was recruited to help. After selecting the top candidate discoveries from a Google search and a PubMed search, the panel was asked to rank them. These final selections were presented at "The Year In Basic Science Session" of the Annual Meeting of the Endocrine Society, ENDO 2010, the highlights of which are reproduced in this article.

Mesh:

Substances:

Year:  2010        PMID: 20880985      PMCID: PMC5417386          DOI: 10.1210/me.2010-0357

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN: 0888-8809


  10 in total

1.  GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Authors:  Nicolas Venteclef; Tomas Jakobsson; Anna Ehrlund; Anastasios Damdimopoulos; Laura Mikkonen; Ewa Ellis; Lisa-Mari Nilsson; Paolo Parini; Olli A Jänne; Jan-Ake Gustafsson; Knut R Steffensen; Eckardt Treuter
Journal:  Genes Dev       Date:  2010-02-15       Impact factor: 11.361

2.  The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis.

Authors:  Michael A Horner; Keith Pardee; Suya Liu; Kirst King-Jones; Gilles Lajoie; Aled Edwards; Henry M Krause; Carl S Thummel
Journal:  Genes Dev       Date:  2009-12-01       Impact factor: 11.361

3.  Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Authors:  Jang Hyun Choi; Alexander S Banks; Jennifer L Estall; Shingo Kajimura; Pontus Boström; Dina Laznik; Jorge L Ruas; Michael J Chalmers; Theodore M Kamenecka; Matthias Blüher; Patrick R Griffin; Bruce M Spiegelman
Journal:  Nature       Date:  2010-07-22       Impact factor: 49.962

4.  Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.

Authors:  Nan Wu; Lei Yin; Elyisha A Hanniman; Shree Joshi; Mitchell A Lazar
Journal:  Genes Dev       Date:  2009-08-26       Impact factor: 11.361

5.  Starvation protects germline stem cells and extends reproductive longevity in C. elegans.

Authors:  Giana Angelo; Marc R Van Gilst
Journal:  Science       Date:  2009-11-13       Impact factor: 47.728

6.  The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.

Authors:  Jian-Chien Dominic Heng; Bo Feng; Jianyong Han; Jianming Jiang; Petra Kraus; Jia-Hui Ng; Yuriy L Orlov; Mikael Huss; Lin Yang; Thomas Lufkin; Bing Lim; Huck-Hui Ng
Journal:  Cell Stem Cell       Date:  2010-01-21       Impact factor: 24.633

7.  Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.

Authors:  Michael K Badman; Anja Koester; Jeffrey S Flier; Alexei Kharitonenkov; Eleftheria Maratos-Flier
Journal:  Endocrinology       Date:  2009-10-09       Impact factor: 4.736

8.  FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

Authors:  Matthew J Potthoff; Takeshi Inagaki; Santhosh Satapati; Xunshan Ding; Tianteng He; Regina Goetz; Moosa Mohammadi; Brian N Finck; David J Mangelsdorf; Steven A Kliewer; Shawn C Burgess
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-16       Impact factor: 11.205

9.  PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.

Authors:  Wei Wei; Xueqian Wang; Marie Yang; Leslie C Smith; Paul C Dechow; Junichiro Sonoda; Ronald M Evans; Yihong Wan
Journal:  Cell Metab       Date:  2010-06-09       Impact factor: 27.287

10.  LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Authors:  Noam Zelcer; Cynthia Hong; Rima Boyadjian; Peter Tontonoz
Journal:  Science       Date:  2009-06-11       Impact factor: 47.728

  10 in total

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