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Literature DB >> 20880709

Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis.

Ioannis P Nezis¹, Antonia P Sagona, Kay Oliver Schink, Harald Stenmark.

Abstract

Cytokinesis is the final step of cell division whereby the dividing cells separate physically. Failure of this process has been proposed to cause tumourigenesis. Several specific lipids are essential for cytokinesis, and recent evidence has revealed that phosphatidylinositol 3-phosphate (PtdIns3P) - a well-known regulator of endosomal trafficking, receptor signaling, nutrient sensing and autophagy - plays an evolutionarily conserved role during cytokinesis. The emerging picture is that PtdIns3P and its regulators and effectors constitute a novel regulatory mechanism for cytokinesis. Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression.

Entities: Chemical Disease

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Year: 2010 PMID： 20880709 DOI： 10.1016/j.tcb.2010.08.010

Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808

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Cited

18 in total

Review 1. Classes of phosphoinositide 3-kinases at a glance.

Authors: Steve Jean; Amy A Kiger
Journal: J Cell Sci Date: 2014-03-01 Impact factor: 5.285

Review 2. Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.

Authors: Eamonn J Dickson; Bertil Hille
Journal: Biochem J Date: 2019-01-07 Impact factor: 3.857

3. A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis.

Authors: Mitsuhiro Abe; Asami Makino; Françoise Hullin-Matsuda; Keiju Kamijo; Yoshiko Ohno-Iwashita; Kentaro Hanada; Hideaki Mizuno; Atsushi Miyawaki; Toshihide Kobayashi
Journal: Mol Cell Biol Date: 2012-02-13 Impact factor: 4.272

Review 4. Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance.

Authors: John A Schiel; Carly Childs; Rytis Prekeris
Journal: Trends Cell Biol Date: 2013-03-20 Impact factor: 20.808

5. Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo.

Authors: Brenda Schumpert; María Guadalupe García; Gary M Wessel; Linda Wordeman; Merrill B Hille
Journal: Mech Dev Date: 2013-01-08 Impact factor: 1.882

Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis.

Review 1. Classes of phosphoinositide 3-kinases at a glance.

Review 2. Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.

3. A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis.

Review 4. Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance.

5. Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo.

6. Mass spectrometry imaging of freeze-dried membrane phospholipids of dividing Tetrahymena pyriformis.

Review 7. Membrane dynamics during cytokinesis.

8. A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis.

9. Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

10. Microtubule-dependent membrane dynamics in Ustilago maydis: Trafficking and function of Rab5a-positive endosomes.