BACKGROUND: Since the 1960s, silicone implants have been successfully used for breast augmentation and reconstruction. However, safety issues regarding the use of silicone have led to a moratorium by the US Food and Drug Administration between 1992 and 2006. DESIGN: To date, although the moratorium has been removed and women overwhelmingly prefer silicone over saline implants, local and systemic adverse effects still remain a concern. RESULTS: Silicone-elicited inflammatory fibro-proliferative response and capsular contracture is irrefutable. Studies on silicone breast implants have not supported a relationship to carcinogenesis, whereas that to autoimmunity mainly to nondefined autoimmune phenomena seems very plausible. These silicone-related autoimmune adverse events termed 'siliconosis' are probably limited to a small minority of implanted patients. CONCLUSIONS: Risk factors, such as characteristic environmental exposure and/or genetic predisposition, still require further elucidation. Similarly to antibacterial agents, texturized implants and Zafirlukast that were found to be beneficial in inhibiting fibro-proliferative response and capsular contracture, elucidating autoimmune-related risk factors might subsequently enable physicians to accurately predict long-term health status of silicone implant recipients.
BACKGROUND: Since the 1960s, silicone implants have been successfully used for breast augmentation and reconstruction. However, safety issues regarding the use of silicone have led to a moratorium by the US Food and Drug Administration between 1992 and 2006. DESIGN: To date, although the moratorium has been removed and women overwhelmingly prefer silicone over saline implants, local and systemic adverse effects still remain a concern. RESULTS:Silicone-elicited inflammatory fibro-proliferative response and capsular contracture is irrefutable. Studies on silicone breast implants have not supported a relationship to carcinogenesis, whereas that to autoimmunity mainly to nondefined autoimmune phenomena seems very plausible. These silicone-related autoimmune adverse events termed 'siliconosis' are probably limited to a small minority of implanted patients. CONCLUSIONS: Risk factors, such as characteristic environmental exposure and/or genetic predisposition, still require further elucidation. Similarly to antibacterial agents, texturized implants and Zafirlukast that were found to be beneficial in inhibiting fibro-proliferative response and capsular contracture, elucidating autoimmune-related risk factors might subsequently enable physicians to accurately predict long-term health status of silicone implant recipients.
Authors: Karlinde Amber Spit; Miranda Scharff; Christel Jm de Blok; Frank B Niessen; Yara Bachour; Prabath W Nanayakkara Journal: BMJ Open Date: 2022-06-09 Impact factor: 3.006
Authors: Carly Fleagle Chisholm; Abby E Baker; Kaitlin R Soucie; Raul M Torres; John F Carpenter; Theodore W Randolph Journal: J Pharm Sci Date: 2016-03-25 Impact factor: 3.534
Authors: Todor I Todorov; Erik de Bakker; Diane Smith; Lisette C Langenberg; Linda A Murakata; Mark H H Kramer; Jose A Centeno; Prabath W B Nanayakkara Journal: Int J Environ Res Public Health Date: 2021-04-24 Impact factor: 3.390