| Literature DB >> 2088002 |
B H Zhang1, N S Wang, X J Li, X J Kong, Y L Cai.
Abstract
Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.Entities:
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Year: 1990 PMID： 2088002
Source DB: PubMed Journal: Zhongguo Yao Li Xue Bao ISSN： 0253-9756