| Literature DB >> 20878700 |
Marina M Padilha1, Fabiana C Vilela, Cláudia Q Rocha, Marcelo J Dias, Roseli Soncini, Marcelo H dos Santos, Geraldo Alves-da-Silva, Alexandre Giusti-Paiva.
Abstract
The aim of the present study was to investigate antiinflammatory activity of the methylene chloride extract of Morus nigra in animal models. Carrageenan-induced paw edema as well as fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the antiinflammatory activity of Morus nigra extract (MnE) in rats. A HPLC fingerprint was used for phytochemical analysis of the extracts. The MnE at test doses of 100-300 mg/kg p.o. clearly demonstrated antiinflammatory effects by reduced paw edema induced by carragenan and significantly inhibited the formation of granulomatous tissue. In addition, chemical compounds isolated from Morus nigra, including betulinic acid, β-sitosterol and germanicol, may be responsible for the antiinflammatory effect of the extract.Entities:
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Year: 2010 PMID： 20878700 DOI： 10.1002/ptr.3134
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878