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Literature DB >> 20878482

Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia.

Kate Bennett¹, Chela James, Khalid Hussain.

Abstract

The pancreatic β-cell ATP-sensitive K(+) channel (K(ATP) channel) plays a critical role in glucose homeostasis by linking glucose metabolism to electrical excitability and insulin secretion. Changes in the intracellular ratio of ATP/ADP mediate the metabolic regulation of channel activity. The β-cell K(ATP) channel is a hetero-octameric complex composed of two types of subunits: four inward-rectifying potassium channel pore-forming (Kir6.2) subunits and four high-affinity sulfonylurea receptor 1 (SUR1) subunits. Kir6.2 and SUR1 are encoded by the genes KCNJ11 and ABCC8, respectively. Mutations in these genes can result in congenital hyperinsulinism and permanent neonatal diabetes. This review highlights the important role of the β-cell K(ATP) channel in glucose physiology and provides an introduction to some of the other review articles in this special edition of the Reviews in Endocrine and Metabolic Disorders.

Entities: Chemical Disease Gene

Mesh：

Substances：
KATP Channels

Year: 2010 PMID： 20878482 DOI： 10.1007/s11154-010-9144-2

Source DB: PubMed Journal: Rev Endocr Metab Disord ISSN： 1389-9155 Impact factor: 6.514

68 in total

1. Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter.

Authors: B Schwappach; N Zerangue; Y N Jan; L Y Jan
Journal: Neuron Date: 2000-04 Impact factor: 17.173

2. Persistent hyperinsulinaemic hypoglycaemia of infancy: a heterogeneous syndrome unrelated to nesidioblastosis.

Authors: J Rahier; Y Guiot; C Sempoux
Journal: Arch Dis Child Fetal Neonatal Ed Date: 2000-03 Impact factor: 5.747

3. Transmembrane topology of the sulfonylurea receptor SUR1.

Authors: L R Conti; C M Radeke; S L Shyng; C A Vandenberg
Journal: J Biol Chem Date: 2001-08-23 Impact factor: 5.157

Review 4. K(ATP) channels and insulin secretion disorders.

Authors: H Huopio; S-L Shyng; T Otonkoski; C G Nichols
Journal: Am J Physiol Endocrinol Metab Date: 2002-08 Impact factor: 4.310

Review 5. Roles of KATP channels as metabolic sensors in acute metabolic changes.

Authors: Takashi Miki; Susumu Seino
Journal: J Mol Cell Cardiol Date: 2005-02-05 Impact factor: 5.000

6. Unbalanced expression of 11p15 imprinted genes in focal forms of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11.

Authors: J C Fournet; C Mayaud; P de Lonlay; M S Gross-Morand; V Verkarre; M Castanet; M Devillers; J Rahier; F Brunelle; J J Robert; C Nihoul-Fékété; J M Saudubray; C Junien
Journal: Am J Pathol Date: 2001-06 Impact factor: 4.307

7. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.

Authors: Anna L Gloyn; Ewan R Pearson; Jennifer F Antcliff; Peter Proks; G Jan Bruining; Annabelle S Slingerland; Neville Howard; Shubha Srinivasan; José M C L Silva; Janne Molnes; Emma L Edghill; Timothy M Frayling; I Karen Temple; Deborah Mackay; Julian P H Shield; Zdenek Sumnik; Adrian van Rhijn; Jerry K H Wales; Penelope Clark; Shaun Gorman; Javier Aisenberg; Sian Ellard; Pål R Njølstad; Frances M Ashcroft; Andrew T Hattersley
Journal: N Engl J Med Date: 2004-04-29 Impact factor: 91.245

8. Parental genomic imprinting of the human IGF2 gene.

Authors: N Giannoukakis; C Deal; J Paquette; C G Goodyer; C Polychronakos
Journal: Nat Genet Date: 1993-05 Impact factor: 38.330

Review 9. Molecular biology of K(ATP) channels and implications for health and disease.

Authors: Alejandro Akrouh; S Eliza Halcomb; Colin G Nichols; Monica Sala-Rabanal
Journal: IUBMB Life Date: 2009-10 Impact factor: 3.885

10. Chromosome 11p15 paternal isodisomy in focal forms of neonatal hyperinsulinism.

Authors: L Damaj; M le Lorch; V Verkarre; C Werl; L Hubert; C Nihoul-Fékété; Y Aigrain; Y de Keyzer; S P Romana; C Bellanne-Chantelot; P de Lonlay; F Jaubert
Journal: J Clin Endocrinol Metab Date: 2008-09-16 Impact factor: 5.958

18 in total

1. Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials.

Authors: Mikako Saito; Aya Hayakawa; Nobuya Inagaki; Hideaki Matsuoka
Journal: Cytotechnology Date: 2012-07-10 Impact factor: 2.058

Review 2. The Pancreatic β-Cell: The Perfect Redox System.

Authors: Petr Ježek; Blanka Holendová; Martin Jabůrek; Jan Tauber; Andrea Dlasková; Lydie Plecitá-Hlavatá
Journal: Antioxidants (Basel) Date: 2021-01-29

3. Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.

Authors: Daniel Oropeza; Marko Horb
Journal: Genesis Date: 2012-01-30 Impact factor: 2.487

Review 4. The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.

Authors: Charles Owen Smith; Keith Nehrke; Paul S Brookes
Journal: Biochem J Date: 2017-06-09 Impact factor: 3.857

Review 5. Genetic and epigenetic control of metabolic health.

Authors: Robert Wolfgang Schwenk; Heike Vogel; Annette Schürmann
Journal: Mol Metab Date: 2013-09-25 Impact factor: 7.422

6. Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro.

Authors: Nathan C Law; Isabella Marinelli; Richard Bertram; Kathryn L Corbin; Cara Schildmeyer; Craig S Nunemaker
Journal: Am J Physiol Endocrinol Metab Date: 2020-02-18 Impact factor: 4.310