Literature DB >> 20877851

Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.

Brad L Pentelute1, Kalyaneswar Mandal, Zachary P Gates, Michael R Sawaya, Todd O Yeates, Stephen B H Kent.   

Abstract

Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

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Year:  2010        PMID： 20877851     DOI： 10.1039/c0cc03148h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

Review 1.  Peptide toxins and small-molecule blockers of BK channels.

Authors:  Mu Yu; San-ling Liu; Pei-bei Sun; Hao Pan; Chang-lin Tian; Long-hua Zhang
Journal:  Acta Pharmacol Sin       Date:  2016-01       Impact factor: 6.150

2.  Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations.

Authors:  David E Mortenson; Kenneth A Satyshur; Ilia A Guzei; Katrina T Forest; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2012-01-18       Impact factor: 15.419

3.  Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain.

Authors:  David E Mortenson; Dale F Kreitler; Hyun Gi Yun; Samuel H Gellman; Katrina T Forest
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2013-11-19

4.  Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio.

Authors:  Dorothee Liebschner; Krzysztof Brzezinski; Miroslawa Dauter; Zbigniew Dauter; Marta Nowak; Józef Kur; Marcin Olszewski
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-11-09

5.  Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue.

Authors:  Zvi Hayouka; David E Mortenson; Dale F Kreitler; Bernard Weisblum; Katrina T Forest; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2013-10-08       Impact factor: 15.419

6.  Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography.

Authors:  Bobo Dang; Tomoya Kubota; Kalyaneswar Mandal; Francisco Bezanilla; Stephen B H Kent
Journal:  J Am Chem Soc       Date:  2013-08-06       Impact factor: 15.419

Review 7.  Mirror image proteins.

Authors:  Le Zhao; Wuyuan Lu
Journal:  Curr Opin Chem Biol       Date:  2014-10-01       Impact factor: 8.822

8.  A crystal-structural study of Pauling-Corey rippled sheets.

Authors:  Ariel J Kuhn; Beatriz Ehlke; Timothy C Johnstone; Scott R J Oliver; Jevgenij A Raskatov
Journal:  Chem Sci       Date:  2021-12-08       Impact factor: 9.825

9.  A new density-modification procedure extending the application of the recent |ρ|-based phasing algorithm to larger crystal structures.

Authors:  Jordi Rius; Xavier Torrelles
Journal:  Acta Crystallogr A Found Adv       Date:  2021-06-21       Impact factor: 2.290

Review 10.  Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering.

Authors:  Zachary L Bergeron; Jon-Paul Bingham
Journal:  Toxins (Basel)       Date:  2012-11-01       Impact factor: 4.546
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