| Literature DB >> 20872994 |
Joel Pinczewski1, Andrzej Slominski.
Abstract
Hormonally active vitamin D3, 1,25-(OH)2D3, is believed to have a role in the prevention of cancer formation and in limiting the aggressiveness of cancers that do arise. Therefore,much interest is presently being focused on 1,25-(OH)2D3 and its analogues as potential treatments for various cancers including melanoma. This article discusses the evidence in favour of a role for 1,25-(OH)2D3 in protection against the progression of melanocytic lesions and also summarizes the mechanisms by which 1,25-(OH)2D3 may act to protect against melanoma development and progression.Entities:
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Year: 2010 PMID: 20872994 PMCID: PMC2947742 DOI: 10.1111/j.1600-0625.2010.01169.x
Source DB: PubMed Journal: Exp Dermatol ISSN: 0906-6705 Impact factor: 3.960