Hongguang Fan1, Zhe Zheng, Wei Feng, Wei Wang, Yunhu Song, Ye Lin, Shengshou Hu. 1. Department of Cardiovascular Surgery and Research Center for Cardiovascular Regenerative Medicine, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167A Beilishi Road, Xi Cheng District, Beijing 100037, PR China.
Abstract
PURPOSE: Upper gastrointestinal (GI) hemorrhage is a serious complication of coronary artery bypass grafting (CABG). The aim of this study was to retrospectively investigate the risk factors and prevention of upper GI bleeding after CABG. METHODS: This study followed 6316 coronary patients who underwent CABG from 1998 to 2005. The perioperative parameters were recorded. Data from patients who experienced major gastrointestinal complications were analyzed retrospectively by univariate and multivariate analyses. RESULTS: The rate of upper GI bleeding was 0.3%. The overall mortality for patients complicated by upper GI bleeding was 47.6%. The risk factors for upper GI bleeding were age (odds ratio [OR] = 3.18, 95% confidence interval [CI] = 1.73-5.87, P < 0.01), extracorporeal circulation time (OR = 1.30, 95% CI = 1.11-1.52, P < 0.01) and the prophylactic use of omeprazole (OR = 0.19, 95% CI = 0.04-0.89, P < 0.05). The long-term mortality was significantly different between the upper GI bleeding group and the controls (P < 0.01). CONCLUSION: Advanced age and extracorporeal circulation time were risk factors for upper GI bleeding after CABG, and the prophylactic use of omeprazole decreased the rate of upper GI bleeding.
PURPOSE: Upper gastrointestinal (GI) hemorrhage is a serious complication of coronary artery bypass grafting (CABG). The aim of this study was to retrospectively investigate the risk factors and prevention of upper GI bleeding after CABG. METHODS: This study followed 6316 coronary patients who underwent CABG from 1998 to 2005. The perioperative parameters were recorded. Data from patients who experienced major gastrointestinal complications were analyzed retrospectively by univariate and multivariate analyses. RESULTS: The rate of upper GI bleeding was 0.3%. The overall mortality for patients complicated by upper GI bleeding was 47.6%. The risk factors for upper GI bleeding were age (odds ratio [OR] = 3.18, 95% confidence interval [CI] = 1.73-5.87, P < 0.01), extracorporeal circulation time (OR = 1.30, 95% CI = 1.11-1.52, P < 0.01) and the prophylactic use of omeprazole (OR = 0.19, 95% CI = 0.04-0.89, P < 0.05). The long-term mortality was significantly different between the upper GI bleeding group and the controls (P < 0.01). CONCLUSION: Advanced age and extracorporeal circulation time were risk factors for upper GI bleeding after CABG, and the prophylactic use of omeprazole decreased the rate of upper GI bleeding.
Authors: Ghassan S Musleh; Nirav C Patel; Antony D Grayson; D Mark Pullan; Daniel J M Keenan; Brian M Fabri; Ragheb Hasan Journal: Eur J Cardiothorac Surg Date: 2003-02 Impact factor: 4.191
Authors: A T Yilmaz; M Arslan; U Demirkilç; E Ozal; E Kuralay; H Bingöl; B S Oz; H Tatar; O Y Oztürk Journal: Eur J Cardiothorac Surg Date: 1996 Impact factor: 4.191
Authors: Fook Hong Ng; Pierre Chan; Chi Pong Kwanching; Ching Kong Loo; Ting Kin Cheung; Siu Yin Wong; Carolyn Kng; Ka Man Ng; Sik To Lai; Benjamin Chun Yu Wong Journal: J Gastroenterol Date: 2008-09-20 Impact factor: 7.527