Literature DB >> 208707

The effect of different calcium concentrations on the inhibitory effect of presynaptic alpha-adrenoceptors in the rat vas deferens.

G M Drew.   

Abstract

The effects of different calcium concentrations on the twitch-inhibitory potency of clonidine and of guanethidine have been examined in the rat isolated vas deferens. Vasa deferentia did not respond to field stimulation at 0.3 Hz in Krebs solution containing 0.325 mmol/1 of calcium. Increasing the calcium concentration to 5.2 mmol/1 caused a concentration-dependent increase in size of the twitch response. The twitch inhibitory potency of clonidine was inversely proportional to the calcium concentration. The inhibitory effect of guanethidine was not influenced by changes in calcium concentration. The results show that the modulation of motor function by presynaptic alpha-adrenoceptors in the rat vas deferens is calcium-dependent.

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Year:  1978        PMID： 208707      PMCID： PMC1668084          DOI： 10.1111/j.1476-5381.1978.tb07792.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

Review 1.  Regulation of noradrenaline release by presynaptic receptor systems.

Authors:  K Starke
Journal:  Rev Physiol Biochem Pharmacol       Date:  1977       Impact factor: 5.545

2.  Pharmacological characterisation of the presynaptic alpha-adrenoceptor in the rat vas deferens.

Authors:  G M Drew
Journal:  Eur J Pharmacol       Date:  1977-03-21       Impact factor: 4.432

3.  The relationship between pre-synaptic alpha-adrenoceptors, stimulation frequency and calcium [proceedings].

Authors:  I Marshall; P A Nasmyth; N B Shepperson
Journal:  Br J Pharmacol       Date:  1977-09       Impact factor: 8.739

Review 4.  Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.

Authors:  S Z Langer
Journal:  Br J Pharmacol       Date:  1977-08       Impact factor: 8.739

5.  Evidence against adrenergic motor transmission in the guinea-pig vas deferens.

Authors:  N Ambache; M A Zar
Journal:  J Physiol       Date:  1971-07       Impact factor: 5.182

6.  The effects of calcium on adrenergic neuron blockade.

Authors:  J Wilson
Journal:  J Pharm Pharmacol       Date:  1970-08       Impact factor: 3.765

7.  Influence of drugs with affinity for alpha-adrenoceptors on noradrenaline release by potassium, tyramine and dimethylphenylpiperazinium.

Authors:  K Starke; H Montel
Journal:  Eur J Pharmacol       Date:  1974-08       Impact factor: 4.432

8.  The mechanism of supersensitivity to norepinephrine induced by cocaine in rat isolated vas deferens.

Authors:  Y Kasuya; K Goto
Journal:  Eur J Pharmacol       Date:  1968-11       Impact factor: 4.432

9.  Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission.

Authors:  E S Vizi; G T Somogyi; P Hadházy; J Knoll
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

10.  [Differences between tyramine and dimethylphenylpiperazine in the Ca++-dependency and in the temporary course of noradrenaline release from the isolated rabbit heart].

Authors:  R Lindmar; K Löffelholz; E Muscholl
Journal:  Experientia       Date:  1967-11-15
  10 in total
  12 in total

1.  Single pulse stimulation of guinea-pig vas deferens and the presynaptic receptor hypothesis.

Authors:  S Kalsner
Journal:  Br J Pharmacol       Date:  1979-06       Impact factor: 8.739

2.  Importance of frequency and pulse with in field stimulation of the mouse vas deferens: different behaviour of twitch-inhibiting drugs.

Authors:  G Zetler; M Kaschube
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-10       Impact factor: 3.000

3.  Mechanism of alpha 2-adrenergic inhibition of neuroeffector transmission in the mouse vas deferens.

Authors:  P Illes; L Dörge
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-01       Impact factor: 3.000

4.  The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.

Authors:  T W Stone
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

5.  The role of calcium in the effects of noradrenaline and phenoxybenzamine on adrenergic transmitter release from atria: no support for negative feedback of release.

Authors:  S Kalsner
Journal:  Br J Pharmacol       Date:  1981-06       Impact factor: 8.739

6.  The mechanism of alpha-adrenergic inhibition of catecholamine release.

Authors:  J Cohen; L Eckstein; Y Gutman
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

7.  Effects of metoclopramide and isoprenaline in the rat vas deferens; interactions with alpha-adrenoceptors.

Authors:  M Spedding
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

8.  An electrophysiological analysis of the effects of morphine on the calcium dependence of neuromuscular transmission in the mouse vas deferens.

Authors:  M R Bennett; N A Lavidis
Journal:  Br J Pharmacol       Date:  1980-06       Impact factor: 8.739

9.  Effect of the dihydropyridine Bay K 8644 on the release of [3H]-noradrenaline from the rat isolated vas deferens.

Authors:  V Ceña; A G García; M A Khoyi; M Salaices; P Sanchez-García
Journal:  Br J Pharmacol       Date:  1985-07       Impact factor: 8.739

10.  Inhibition of noradrenaline release by omega-conotoxin GVIA in the rat tail artery.

Authors:  B Clasbrummel; H Osswald; P Illes
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739
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