| Literature DB >> 20870413 |
Hyunmin Song1, Sei-Ryang Oh, Hyeong-Kyu Lee, Gyoonhee Han, Joo-Heon Kim, Hyeun Wook Chang, Kyung-Eun Doh, Hee-Kyung Rhee, Hea-Young Park Choo.
Abstract
5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC(50) value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness.Entities:
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Year: 2010 PMID： 20870413 DOI： 10.1016/j.bmc.2010.08.047
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641