| Literature DB >> 20870401 |
A J Fiocco1, A M Kanaya, K M Lindquist, T B Harris, S Satterfield, E M Simonsick, L Kuller, C Rosano, K Yaffe.
Abstract
F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults. Copyright ÂEntities:
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Year: 2010 PMID: 20870401 PMCID: PMC3015004 DOI: 10.1016/j.plefa.2010.09.001
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN: 0952-3278 Impact factor: 4.006