Literature DB >> 2087009

Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells.

T Fujimura1, H Shibata, I Maekawa, S Furusawa, H Kawauchi, K Sasaki, Y Takayanagi.   

Abstract

Cytotoxic effect in vitro and antitumor effect in vivo of doxorubicin (DOX) combined with cepharanthine were investigated on DOX-resistant murine P388 leukemia (P388/R) cells. Cepharanthine was minimally cytotoxic in the cell line, but reversed DOX-resistance in a dose-related manner in P388/R cells. The administration of cepharanthine to mice bearing the P388 leukemia enhanced the antitumor activity of DOX. These results indicate that cepharanthine is an effective agent to reverse DOX-resistant cells.

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Year:  1990        PMID： 2087009     DOI： 10.1254/jjp.54.464

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  6 in total

1.  Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells.

Authors:  Zan Chen; Chen Huang; Yan-ling Yang; Yi Ding; Han-qiang Ou-Yang; You-yi Zhang; Ming Xu
Journal:  Acta Pharmacol Sin       Date:  2012-01       Impact factor: 6.150

Review 2.  Genetics and epigenetics of autoimmune thyroid diseases: Translational implications.

Authors:  Hanna J Lee; Mihaela Stefan-Lifshitz; Cheuk Wun Li; Yaron Tomer
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2022-04-11       Impact factor: 5.667

3.  Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage.

Authors:  Dorota Halicka; Masamichi Ita; Toshiki Tanaka; Akira Kurose; Zbigniew Darzynkiewicz
Journal:  Pharmacol Rep       Date:  2008 Jan-Feb       Impact factor: 3.024

4.  Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines.

Authors:  Masamichi Ita; H Dorota Halicka; Toshiki Tanaka; Akira Kurose; Barbara Ardelt; Kuslima Shogen; Zbigniew Darzynkiewicz
Journal:  Cancer Biol Ther       Date:  2008-04-19       Impact factor: 4.742

5.  Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis.

Authors:  Cheuk Wun Li; Francesca Menconi; Roman Osman; Mihaly Mezei; Eric M Jacobson; Erlinda Concepcion; Chella S David; David B Kastrinsky; Michael Ohlmeyer; Yaron Tomer
Journal:  J Biol Chem       Date:  2015-12-24       Impact factor: 5.157

6.  Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model.

Authors:  Cheuk Wun Li; Roman Osman; Francesca Menconi; Larissa C Faustino; Kookjoo Kim; Oliver B Clarke; Hanxi Hou; Yaron Tomer
Journal:  Front Immunol       Date:  2021-12-20       Impact factor: 7.561
  6 in total

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