The development of the science of dreaming.

Although the main peripheral features of dreaming were identified two millennia ago, the neurobiological study of the basic and higher integrated processes underlying rapid eye movement (REM) sleep only began about 70 years ago. Today, the combined contributions of the successive and complementary methods of electrophysiology, imaging, pharmacology, and neurochemistry have provided a good level of knowledge of the opposite but complementary activating and inhibitory processes which regulate waking mentation and which are disturbed during REM sleep, inducing a schizophrenic-like mental activity.