Literature DB >> 20869871

Biologically active biotin derivatives of schweinfurthin F.

Natalie C Ulrich1, Craig H Kuder, Raymond J Hohl, David F Wiemer.   

Abstract

As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20869871     DOI： 10.1016/j.bmcl.2010.08.143

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis of indole analogues of the natural schweinfurthins.

Authors:  John G Kodet; David F Wiemer
Journal:  J Org Chem       Date:  2013-09-05       Impact factor: 4.354

2.  Synthesis and structure activity relationships of schweinfurthin indoles.

Authors:  John G Kodet; John A Beutler; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2014-03-06       Impact factor: 3.641

3.  Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

Authors:  Kathleen M Kokolus; Jeremy S Haley; Emily J Koubek; Raghavendra Gowda; Saketh S Dinavahi; Arati Sharma; David F Claxton; Klaus F Helm; Joseph J Drabick; Gavin P Robertson; Jeffrey D Neighbors; Raymond J Hohl; Todd D Schell
Journal:  Oncoimmunology       Date:  2018-11-11       Impact factor: 8.110

4.  Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

Authors:  Joseph J Topczewski; Michael P Callahan; John G Kodet; Jery D Inbarasu; Nolan R Mente; John A Beutler; David F Wiemer
Journal:  Bioorg Med Chem       Date:  2011-10-19       Impact factor: 3.641

5.  Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.

Authors:  Joseph J Topczewski; John G Kodet; David F Wiemer
Journal:  J Org Chem       Date:  2011-01-12       Impact factor: 4.354

6.  3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines.

Authors:  Craig H Kuder; Megan M Weivoda; Ying Zhang; Junjia Zhu; Jeffrey D Neighbors; David F Wiemer; Raymond J Hohl
Journal:  Lipids       Date:  2015-10-22       Impact factor: 1.880
  6 in total

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