Literature DB >> 20869124

Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide.

Jasminka Stefulj1, Gordana Mokrovic, Dubravka Hranilovic, Tatjana Bordukalo-Niksic, Mirko Bakula, Milovan Kubat, Branimir Jernej.   

Abstract

The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion.
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID: 20869124     DOI: 10.1016/j.psychres.2010.08.034

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  8 in total

Review 1.  Toward a biosignature for suicide.

Authors:  Maria A Oquendo; Gregory M Sullivan; Katherin Sudol; Enrique Baca-Garcia; Barbara H Stanley; M Elizabeth Sublette; J John Mann
Journal:  Am J Psychiatry       Date:  2014-10-31       Impact factor: 18.112

Review 2.  The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse.

Authors:  Jacob P R Jacobsen; Ivan O Medvedev; Marc G Caron
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-09-05       Impact factor: 6.237

3.  Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides.

Authors:  Helene Bach; Victoria Arango; Suham A Kassir; Andrew J Dwork; J John Mann; Mark D Underwood
Journal:  Arch Suicide Res       Date:  2016-03-08

Review 4.  The role of the serotonergic system at the interface of aggression and suicide.

Authors:  M Bortolato; N Pivac; D Muck Seler; M Nikolac Perkovic; M Pessia; G Di Giovanni
Journal:  Neuroscience       Date:  2013-01-16       Impact factor: 3.590

Review 5.  Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.

Authors:  Bojan Mirkovic; Claudine Laurent; Marc-Antoine Podlipski; Thierry Frebourg; David Cohen; Priscille Gerardin
Journal:  Front Psychiatry       Date:  2016-09-23       Impact factor: 4.157

6.  The Life Span Model of Suicide and Its Neurobiological Foundation.

Authors:  Birgit Ludwig; Bhaskar Roy; Qingzhong Wang; Badari Birur; Yogesh Dwivedi
Journal:  Front Neurosci       Date:  2017-02-14       Impact factor: 4.677

7.  Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence.

Authors:  Siddharth Sarkar; Renu Singh; Arundhati Sharma; Muzaffar A Pandit; Ranjan Gupta; Deepika Singhal; Raka Jain; Yatan P Balhara
Journal:  Cureus       Date:  2021-11-06

Review 8.  Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.

Authors:  Thelma Beatriz González-Castro; Isela Juárez-Rojop; María Lilia López-Narváez; Carlos Alfonso Tovilla-Zárate
Journal:  BMC Psychiatry       Date:  2014-07-08       Impact factor: 3.630

  8 in total

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