Literature DB >> 20868688

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.

Xiaojun Liu1, Aijun Qiao, Yaojun Ke, Xingxing Kong, Jichao Liang, Rui Wang, Xiaoqing Ouyang, Ji Zuo, Yongsheng Chang, Fude Fang.   

Abstract

Recent studies have demonstrated that FoxO1 modulates the expression of SREBP-1c, but the exact mechanism remains unknown. Our results demonstrate that FoxO1 suppresses the SREBP-1c promoter transcriptional activity in HepG2 cells. This repression was independent of FoxO1 binding to the SREBP-1c promoter, but LXR responsive elements (LXREs) were crucial to this phenomenon. Moreover, FoxO1 also strongly inhibited the LXRα-mediated elevated transcription by SREBP-1c promoter. Electrophoretic mobility shift assay and chromatin immuno-precipitation further suggested the ability of FoxO1 to inhibit LXRα binding with the LXRE in the SREBP-1c promoter. FoxO1-mediated suppression of SREBP-1c promoter activity could be partially alleviated by insulin.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20868688     DOI： 10.1016/j.febslet.2010.09.027

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c.

Authors:  Xiong Deng; Wenwei Zhang; InSug O-Sullivan; J Bradley Williams; Qingming Dong; Edwards A Park; Rajendra Raghow; Terry G Unterman; Marshall B Elam
Journal:  J Biol Chem       Date:  2012-04-16       Impact factor: 5.157

2.  Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice.

Authors:  Jayong Chung; Kyeongok Koo; Fuzhi Lian; Kang Quan Hu; Hansgeorg Ernst; Xiang-Dong Wang
Journal:  J Nutr       Date:  2012-01-18       Impact factor: 4.798

Review 3.  G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux.

Authors:  Xiaodong Zhang; Bradlee L Heckmann; Latoya E Campbell; Jun Liu
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2017-06-21       Impact factor: 4.698

Review 4.  Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.

Authors:  Bodo C Melnik
Journal:  Clin Cosmet Investig Dermatol       Date:  2015-07-15

5.  FOXO transcription factors protect against the diet-induced fatty liver disease.

Authors:  Xiaoyan Pan; Yang Zhang; Hyeong-Geug Kim; Suthat Liangpunsakul; X Charlie Dong
Journal:  Sci Rep       Date:  2017-03-16       Impact factor: 4.379

6.  FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin.

Authors:  Yoshinori Takeuchi; Naoya Yahagi; Yuichi Aita; Zahra Mehrazad-Saber; Man Hei Ho; Yiren Huyan; Yuki Murayama; Akito Shikama; Yukari Masuda; Yoshihiko Izumida; Takafumi Miyamoto; Takashi Matsuzaka; Yasushi Kawakami; Hitoshi Shimano
Journal:  iScience       Date:  2021-11-15

7.  Effects of 2-Methoxyestradiol, a Main Metabolite of Estradiol on Hepatic ABCA1 Expression in HepG2 Cells.

Authors:  Tomohiro Ibata; Jingya Lyu; Hitomi Imachi; Kensaku Fukunaga; Seisuke Sato; Toshihiro Kobayashi; Takanobu Saheki; Takafumi Yoshimura; Koji Murao
Journal:  Nutrients       Date:  2022-01-11       Impact factor: 5.717

Review 8.  Insulin-Responsive Transcription Factors.

Authors:  Gerald Thiel; Lisbeth A Guethlein; Oliver G Rössler
Journal:  Biomolecules       Date:  2021-12-15
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.