Literature DB >> 20866101

Enamides accessed from aminothioesters via a Pd(0)-catalyzed decarbonylative/β-hydride elimination sequence.

Geanna K Min1, Dácil Hernández, Anders T Lindhardt, Troels Skrydstrup.   

Abstract

A facile synthesis of various enamides from aminothioesters via a palladium(0)-catalyzed decarbonylation/β-hydride elimination is reported. This protocol was applied to mercaptopyridyl C-terminal modified peptides for the generation of enamides without epimerization at stereogenic centers.

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Year:  2010        PMID： 20866101     DOI： 10.1021/ol101620r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Decarbonylative approach to the synthesis of enamides from amino acids: stereoselective synthesis of the (Z)-aminovinyl-D-cysteine unit of mersacidin.

Authors:  Pablo García-Reynaga; Angela K Carrillo; Michael S VanNieuwenhze
Journal:  Org Lett       Date:  2012-02-01       Impact factor: 6.005

2.  Irradiation-induced palladium-catalyzed decarboxylative desaturation enabled by a dual ligand system.

Authors:  Wan-Min Cheng; Rui Shang; Yao Fu
Journal:  Nat Commun       Date:  2018-12-06       Impact factor: 14.919
  2 in total

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