Literature DB >> 20865508

GNCPro: navigate human genes and relationships through net-walking.

Guozhen Gordon Liu1, Elvena Fong, Xiao Zeng.   

Abstract

UNLABELLED: The use of computational applications in biological research is significantly lagging behind other scientific research areas such as physics, mathematics, and geology; more in silico tools are needed. The increasing complexity of biological data makes it more and more difficult for scientists to verify their hypotheses and results against existing discoveries. GNCPro is a free data integration and visualization tool for gaining comprehensive overviews of such complicated biological knowledge. In particular, GNCPro warehouses and encodes biological information as binary relationships. When represented graphically, these binary relationships take on the form of edges that connect the genes and proteins, which are represented by nodes. By using distinguishing features such as colors, shape, and opacity, GNCPro provides a stimulating visual experience in which the user can quickly identify groups of genes by annotations and the types of relationships involved. GNCPro integrates human gene expressions, regulations, gene product modifications, and interactions into one platform while delivering a simple and powerful user interface for systems biology study. AVAILABILITY: http://GNCPro.sabiosciences.com.

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Year:  2010        PMID: 20865508     DOI: 10.1007/978-1-4419-5913-3_29

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  6 in total

1.  A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions.

Authors:  Bryan H Chang; Taranjit S Gujral; Ethan S Karp; Raghida BuKhalid; Viara P Grantcharova; Gavin MacBeath
Journal:  Chem Biol       Date:  2011-09-23

2.  Gene network effects on brain microstructure and intellectual performance identified in 472 twins.

Authors:  Ming-Chang Chiang; Marina Barysheva; Katie L McMahon; Greig I de Zubicaray; Kori Johnson; Grant W Montgomery; Nicholas G Martin; Arthur W Toga; Margaret J Wright; Paul Shapshak; Paul M Thompson
Journal:  J Neurosci       Date:  2012-06-20       Impact factor: 6.167

3.  Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays.

Authors:  T S Gujral; R L Karp; A Finski; M Chan; P E Schwartz; G MacBeath; P Sorger
Journal:  Oncogene       Date:  2012-09-03       Impact factor: 9.867

4.  A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools.

Authors:  Emmanouil I Athanasiadis; Kyriaki Antonopoulou; Foteini Chatzinasiou; Christina M Lill; Marilena M Bourdakou; Argiris Sakellariou; Katerina Kypreou; Irene Stefanaki; Evangelos Evangelou; John P A Ioannidis; Lars Bertram; Alexander J Stratigos; George M Spyrou
Journal:  Database (Oxford)       Date:  2014-11-07       Impact factor: 3.451

5.  Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease.

Authors:  Andrew J Levine; Jeremy A Miller; Paul Shapshak; Benjamin Gelman; Elyse J Singer; Charles H Hinkin; Deborah Commins; Susan Morgello; Igor Grant; Steve Horvath
Journal:  BMC Med Genomics       Date:  2013-02-13       Impact factor: 3.063

6.  Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells.

Authors:  Weiqiang Zhou; Xiuyan Feng; Shanchun Guo; Guangdi Wang
Journal:  Sci Rep       Date:  2016-06-13       Impact factor: 4.379

  6 in total

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