Literature DB >> 20865461

Epigenetic regulation of retinoic acid receptor β2 gene in the initiation of breast cancer.

Jingyan Sun1, Xu Xu, Juntian Liu, Hong Liu, Li Fu, Lin Gu.   

Abstract

In order to investigate the methylation status of the retinoic acid receptor beta 2 gene (RAR-β2) in breast carcinoma in relation to gene expression and clinicopathological parameters of patients with breast cancer, expression of RAR-β2 gene and methylation status were analyzed in invasive carcinoma, atypical ductal hyperplasia, fibroadenoma specimens, and normal tissues. Our findings showed that RAR-β2 expression was lower in the breast cancer compared to normal tissue and fibroadenoma. The methylation rate of RAR-β2 in breast cancer and precancerous lesions of breast cancer were higher than that of normal tissues. Hypermethylation may be an initial step in breast carcinogenesis.

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Year:  2011        PMID： 20865461     DOI： 10.1007/s12032-010-9685-y

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  32 in total

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3.  BRCA2 carriers with male breast cancer show elevated tumour methylation.

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Review 4.  Retinoic Acids in the Treatment of Most Lethal Solid Cancers.

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