Literature DB >> 20865132

Histone Deacetylase Inhibitors: Synthesis of Cyclic Tetrapeptides and their Triazole Analogues.

Erinprit K Singh1, Lidia A Nazarova, Stephanie A Lapera, Leslie D Alexander, Shelli R McAlpine.   

Abstract

Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives are described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrates that incorporation of a triazole unit improves the HDAC inhibitory activity.

Entities:  

Year:  2010        PMID： 20865132      PMCID： PMC2941989          DOI： 10.1016/j.tetlet.2010.06.050

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  17 in total

Review 1.  DNA methylation, methyltransferases, and cancer.

Authors:  K D Robertson
Journal:  Oncogene       Date:  2001-05-28       Impact factor: 9.867

Review 2.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

Authors:  Saverio Minucci; Pier Giuseppe Pelicci
Journal:  Nat Rev Cancer       Date:  2006-01       Impact factor: 60.716

Review 3.  Clinical studies of histone deacetylase inhibitors.

Authors:  H Miles Prince; Mark J Bishton; Simon J Harrison
Journal:  Clin Cancer Res       Date:  2009-06-09       Impact factor: 12.531

4.  Synthesis of ciclosporin and analogues: structural and conformational requirements for immunosuppressive activity.

Authors:  R M Wenger
Journal:  Prog Allergy       Date:  1986

5.  Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.

Authors:  J T Lundquist ; J C Pelletier
Journal:  Org Lett       Date:  2001-03-08       Impact factor: 6.005

Review 6.  Histone deacetylase inhibitors as new cancer drugs.

Authors:  P A Marks; V M Richon; R Breslow; R A Rifkind
Journal:  Curr Opin Oncol       Date:  2001-11       Impact factor: 3.645

7.  Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Authors:  S J Darkin-Rattray; A M Gurnett; R W Myers; P M Dulski; T M Crumley; J J Allocco; C Cannova; P T Meinke; S L Colletti; M A Bednarek; S B Singh; M A Goetz; A W Dombrowski; J D Polishook; D M Schmatz
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

Review 8.  Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.

Authors:  Ricky W Johnstone
Journal:  Nat Rev Drug Discov       Date:  2002-04       Impact factor: 84.694

9.  FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.

Authors:  Bhupinder S Mann; John R Johnson; Martin H Cohen; Robert Justice; Richard Pazdur
Journal:  Oncologist       Date:  2007-10

Review 10.  The many roles of histone deacetylases in development and physiology: implications for disease and therapy.

Authors:  Michael Haberland; Rusty L Montgomery; Eric N Olson
Journal:  Nat Rev Genet       Date:  2009-01       Impact factor: 53.242
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  2 in total

1.  Solid phase versus solution phase synthesis of heterocyclic macrocycles.

Authors:  Seong Jong Kim; Shelli R McAlpine
Journal:  Molecules       Date:  2013-01-16       Impact factor: 4.411

Review 2.  1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity.

Authors:  Lisa-Maria Rečnik; Wolfgang Kandioller; Thomas L Mindt
Journal:  Molecules       Date:  2020-08-06       Impact factor: 4.411
  2 in total

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