OBJECTIVE: To determine the burden of enteric fever through trends in morbidity and mortality, bacterial species and antimicrobial resistance in Guangxi, a southern, subtropical, coastal province of China with a disproportionally large burden of enteric fever. METHODS: Data on morbidity and mortality caused by enteric fever between 1994 and 2004 were extracted from the Guangxi Center for Disease Control and Prevention. Laboratory-based surveillance and outbreak investigations were integrated with reports of notifiable infectious diseases to estimate the bacterial species-specific incidence of enteric fever. To adjust for underreporting, survey data were collected from three prefectures that represent the hyper-, moderate- and low-endemic regions of Guangxi province. FINDINGS: In Guangxi province, enteric fever incidence rate varied over the study period, with a peak of 13.5 cases per 100 000 population in 1995 and a low of 6.5 in 2003. The disease occurred most frequently during the summer and autumn months and in the group aged 10-49 years. The incidence of enteric fever varied by region within Guangxi province. During the 11-year period covered by the study, 61 outbreaks of enteric fever were reported, and Salmonella paratyphi A (SPA) became the predominant causative agent in the province. CONCLUSION: Prospective studies may provide a better understanding of the reason for the shifting epidemiology of enteric fever in Guangxi province. Given the emergence of resistance to first- and second-line antimicrobials for the treatment of enteric fever, a bivalent vaccine against both SPA and S. typhi would facilitate for disease control.
OBJECTIVE: To determine the burden of enteric fever through trends in morbidity and mortality, bacterial species and antimicrobial resistance in Guangxi, a southern, subtropical, coastal province of China with a disproportionally large burden of enteric fever. METHODS: Data on morbidity and mortality caused by enteric fever between 1994 and 2004 were extracted from the Guangxi Center for Disease Control and Prevention. Laboratory-based surveillance and outbreak investigations were integrated with reports of notifiable infectious diseases to estimate the bacterial species-specific incidence of enteric fever. To adjust for underreporting, survey data were collected from three prefectures that represent the hyper-, moderate- and low-endemic regions of Guangxi province. FINDINGS: In Guangxi province, enteric fever incidence rate varied over the study period, with a peak of 13.5 cases per 100 000 population in 1995 and a low of 6.5 in 2003. The disease occurred most frequently during the summer and autumn months and in the group aged 10-49 years. The incidence of enteric fever varied by region within Guangxi province. During the 11-year period covered by the study, 61 outbreaks of enteric fever were reported, and Salmonella paratyphi A (SPA) became the predominant causative agent in the province. CONCLUSION: Prospective studies may provide a better understanding of the reason for the shifting epidemiology of enteric fever in Guangxi province. Given the emergence of resistance to first- and second-line antimicrobials for the treatment of enteric fever, a bivalent vaccine against both SPA and S. typhi would facilitate for disease control.
Authors: J Wain; N T Hoa; N T Chinh; H Vinh; M J Everett; T S Diep; N P Day; T Solomon; N J White; L J Piddock; C M Parry Journal: Clin Infect Dis Date: 1997-12 Impact factor: 9.079
Authors: Francesca Micoli; Simona Rondini; Massimiliano Gavini; Luisa Lanzilao; Donata Medaglini; Allan Saul; Laura B Martin Journal: PLoS One Date: 2012-11-07 Impact factor: 3.240
Authors: Michael B Arndt; Emily M Mosites; Mu Tian; Mohammad H Forouzanfar; Ali H Mokhdad; Margaret Meller; Rion L Ochiai; Judd L Walson Journal: PLoS Negl Trop Dis Date: 2014-06-05
Authors: Raphaël M Zellweger; Buddha Basnyat; Poojan Shrestha; Krishna G Prajapati; Sabina Dongol; Paban K Sharma; Samir Koirala; Thomas C Darton; Christiane Dolecek; Corinne N Thompson; Guy E Thwaites; Stephen G Baker; Abhilasha Karkey Journal: PLoS Negl Trop Dis Date: 2017-11-27
Authors: Li Zhang; Di Xiao; Bo Pang; Qian Zhang; Haijian Zhou; Lijuan Zhang; Jianzhong Zhang; Biao Kan Journal: PLoS One Date: 2014-02-24 Impact factor: 3.240