OBJECTIVE: in this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats. MATERIALS AND METHODS: oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney. RESULTS: in NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. On the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content. CONCLUSIONS: in addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. 2010 Elsevier Ltd. All rights reserved.
OBJECTIVE: in this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensiverats. MATERIALS AND METHODS: oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney. RESULTS: in NO-deficient hypertensiverats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. On the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to periodontitis were observed in cardiac or renal TBARS content. CONCLUSIONS: in addition to mediating alveolar bone loss, NO contributes to systemic effects of periodontitis in the heart and kidney. 2010 Elsevier Ltd. All rights reserved.
Authors: Z Lohinai; P Benedek; E Fehér; A Györfi; L Rosivall; A Fazekas; A L Salzman; C Szabó Journal: Br J Pharmacol Date: 1998-02 Impact factor: 8.739
Authors: R Di Paola; S Marzocco; E Mazzon; F Dattola; F Rotondo; D Britti; M De Majo; T Genovese; S Cuzzocrea Journal: J Dent Res Date: 2004-04 Impact factor: 6.116
Authors: Volker Adams; Britta Nehrhoff; Ulrike Späte; Axel Linke; Paul C Schulze; Angelika Baur; Stephan Gielen; Rainer Hambrecht; Gerhard Schuler Journal: Cardiovasc Res Date: 2002-04 Impact factor: 10.787
Authors: Bruno S Herrera; Rodrigo Martins-Porto; Aline Maia-Dantas; Paula Campi; Luis C Spolidorio; Soraia K P Costa; Thomas E Van Dyke; Robert Gyurko; Marcelo N Muscara Journal: J Periodontol Date: 2011-03-21 Impact factor: 6.993
Authors: Eduardo Ekundi-Valentim; Filiphe Pn Mesquita; Karen T Santos; Marco A Vieira de Paula; Juliana Florenzano; Cristiane I Zanoni; Leandro Rodrigues; Gilberto de Nucci; Simone A Teixeira; Heloisa Ha Ferreira; John L Wallace; Soraia Kp Costa; Marcelo N Muscará Journal: Med Gas Res Date: 2013-11-16
Authors: Bruno Schneider Herrera; Leila Santana Coimbra; Agatha Ribeiro da Silva; Simone Aparecida Teixeira; Soraia Katia Pereira Costa; John Lawrence Wallace; Luis Carlos Spolidorio; Marcelo Nicolas Muscara Journal: Med Gas Res Date: 2015-02-27