Literature DB >> 2086241

Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus.

A Pittaluga1, M Raiteri.   

Abstract

The release of [3H]noradrenaline ([3H]NA) in superfused rat hippocampal synaptosomes was increased concentration dependently by N-methyl-D-aspartate (NMDA). Glycine (1 microM), ineffective on its own, doubled the efficacy of NMDA with no significant change in affinity. The effects of NMDA alone and those of NMDA + glycine were antagonized by D-2-amino-5-phosphonopentanoate (D-AP5), Mg2+, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohept-5,10-imine hydrogen maleate (MK-801) or 7-chloro-kynurenate (7-Cl-KYNA) but not by strychnine. The data provide a direct demonstration of the existence of presynaptic NMDA receptors.

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Year:  1990        PMID： 2086241     DOI： 10.1016/0014-2999(90)94153-o

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  33 in total

Review 1.  Synaptosomes still viable after 25 years of superfusion.

Authors:  L Raiteri; M Raiteri
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

2.  Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn.

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3.  Ornithine decarboxylase activity in cerebral post-ischemic reperfusion damage: effect of methionine sulfoximine.

Authors:  C Di Giacomo; V Sorrenti; R Acquaviva; A Campisi; G Vanella; J R Perez-Polo; A Vanella
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4.  Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release.

Authors:  Anna Pittaluga; Daniela Segantini; Marco Feligioni; Maurizio Raiteri
Journal:  Br J Pharmacol       Date:  2005-01       Impact factor: 8.739

5.  Somatostatin potentiates NMDA receptor function via activation of InsP(3) receptors and PKC leading to removal of the Mg(2+) block without depolarization.

Authors:  A Pittaluga; A Bonfanti; M Raiteri
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

6.  Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons.

Authors:  M Glitsch; A Marty
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

7.  Release of endogenous adenosine and its metabolites by the activation of NMDA receptors in the rat hippocampus in vivo.

Authors:  Y Chen; D I Graham; T W Stone
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

8.  N-methyl-D-aspartate (NMDA)-stimulated noradrenaline (NA) release in rat brain cortex is modulated by presynaptic H3-receptors.

Authors:  K Fink; E Schlicker; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-02       Impact factor: 3.000

9.  Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.

Authors:  K Fink; R Schultheiss; M Göthert
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739

10.  Preferential location of N-methyl-D-aspartate (NMDA) receptors on postsynaptic membranes and on non-noradrenergic nerve terminals of the rat brain cortex.

Authors:  K Fink; M Blohm; G Molderings; H Bönisch; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-06       Impact factor: 3.000
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