Literature DB >> 2086240

Inhibition of N-methyl-D-aspartate-induced noradrenaline release by alcohols is related to their hydrophobicity.

K Fink1, M Göthert.   

Abstract

In rat brain cortex slices, ethanol was three times more potent in inhibiting [3H]noradrenaline ([3H]NA) release evoked by N-methyl-D-aspartate (NMDA) than in inhibiting the release evoked by kainic acid. Methanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol shared the inhibitory property of ethanol on NMDA-evoked [3H]NA release. The inhibitory potency of the alcohols, as expressed by their IC50 values, was correlated with their membrane/buffer partition coefficient. It is concluded that the inhibitory effect of the alcohols may be due to a hydrophobic interaction with the NMDA receptor system.

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Year:  1990        PMID： 2086240     DOI： 10.1016/0014-2999(90)94152-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Ethanol inhibits the N-methyl-D-aspartate (NMDA)-induced attenuation of the NMDA-evoked noradrenaline release in the rat brain cortex: interaction with NMDA-induced desensitization.

Authors:  K Fink; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-08       Impact factor: 3.000

2.  Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication.

Authors:  R W Peoples; F F Weight
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

3.  Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.

Authors:  K Fink; R Schultheiss; M Göthert
Journal:  Br J Pharmacol       Date:  1992-05       Impact factor: 8.739

4.  Inhibition of N-methyl-D-aspartate- and kainate-evoked noradrenaline release in human cerebral cortex slices by ethanol.

Authors:  K Fink; R Schultheiss; M Göthert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-06       Impact factor: 3.000

5.  Inhibition by ethanol of excitatory amino acid receptors and nicotinic acetylcholine receptors at rat locus coeruleus neurons.

Authors:  R Fröhlich; C Patzelt; P Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000

6.  Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects.

Authors:  J E Dildy-Mayfield; S J Mihic; Y Liu; R A Deitrich; R A Harris
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739

Review 7.  Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).

Authors:  H Bönisch; K B Fink; B Malinowska; G J Molderings; E Schlicker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2021-05-15       Impact factor: 3.000
  7 in total

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