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Literature DB >> 20859770

Stem cell-based therapeutic applications in retinal degenerative diseases.

Yiming Huang¹, Volker Enzmann, Suzanne T Ildstad.

Abstract

Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma. Effective treatment for retinal degeneration has been widely investigated. Gene-replacement therapy has been shown to improve visual function in inherited retinal disease. However, this treatment was less effective with advanced disease. Stem cell-based therapy is being pursued as a potential alternative approach in the treatment of retinal degenerative diseases. In this review, we will focus on stem cell-based therapies in the pipeline and summarize progress in treatment of retinal degenerative disease.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 20859770 PMCID： PMC3408315 DOI： 10.1007/s12015-010-9192-8

Source DB: PubMed Journal: Stem Cell Rev Rep ISSN： 2629-3277 Impact factor: 5.739

145 in total

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32 in total

Review 1. The rod photoreceptor lineage of teleost fish.

Authors: Deborah L Stenkamp
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Authors: Hamid Aboutaleb Kadkhodaeian; Taki Tiraihi; Hamid Ahmadieh; Hossein Ziaei; Narsis Daftarian; Taher Taheri
Journal: Tissue Eng Regen Med Date: 2019-05-03 Impact factor: 4.169

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Journal: Graefes Arch Clin Exp Ophthalmol Date: 2015-02-14 Impact factor: 3.117

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7. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression.

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Journal: Graefes Arch Clin Exp Ophthalmol Date: 2014-05-13 Impact factor: 3.117