Literature DB >> 2085732

Evidence that 5 alpha-pregnan-3 alpha-ol-20-one is the metabolite responsible for progesterone anesthesia.

W M Mok1, N R Krieger.   

Abstract

Tadpoles (Rana catesbeiana) were anesthetized with [3H]-progesterone (PG) in order to identify the steroid responsible for anesthesia. PG and its metabolites in brain were resolved (HPLC) and quantitated following sacrifice at different behavioral endpoints. The results support the hypothesis that 5 alpha-pregnan-3 alpha-ol-20-one mediates the loss and the return of the righting response. The observed levels for PG were not consistent with such a role. Neither PG nor 5 alpha-pregnan-3 alpha-ol-20-one produced analgesia.

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Year:  1990        PMID： 2085732     DOI： 10.1016/0006-8993(90)91792-f

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

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Authors:  Jason D Kilts; Larry A Tupler; Francis J Keefe; Victoria M Payne; Robert M Hamer; Jennifer C Naylor; Rohana P Calnaido; Rajendra A Morey; Jennifer L Strauss; Gillian Parke; Mark W Massing; Nagy A Youssef; Lawrence J Shampine; Christine E Marx
Journal:  Pain Med       Date:  2010-08-23       Impact factor: 3.750

2.  Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor.

Authors:  D Bitran; J A Dowd
Journal:  Psychopharmacology (Berl)       Date:  1996-05       Impact factor: 4.530

3.  Termination of pseudopregnancy in the rat alters the response to progesterone, chlordiazepoxide, and MK-801 in the elevated plus-maze.

Authors:  Daniel Bitran; Steven M Solano
Journal:  Psychopharmacology (Berl)       Date:  2005-02-08       Impact factor: 4.530

4.  Effect of an oral contraceptive with chlormadinone acetate on depressive mood : analysis of data from four observational studies.

Authors:  Johannes C Huber; Marie-Luise S Heskamp; Georg A K Schramm
Journal:  Clin Drug Investig       Date:  2008       Impact factor: 2.859

5.  Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes.

Authors:  D S Reddy; Y-C Zeng
Journal:  Methods Find Exp Clin Pharmacol       Date:  2007-12

6.  Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task.

Authors:  Cheryl A Frye; Caryn K Duffy; Alicia A Walf
Journal:  Neurobiol Learn Mem       Date:  2007-05-15       Impact factor: 2.877
  6 in total

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