| Literature DB >> 2085727 |
Abstract
The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 microgram of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures.Entities:
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Year: 1990 PMID： 2085727 DOI： 10.1016/0006-8993(90)91810-4
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252